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Calcium in Drug Actions pp 163–183Cite as

Development of Inhibitors of Sodium, Calcium Exchange

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 83))

Abstract

Electrically excitable cells process the Ca2+ which triggers excitation-response coupling in an efficient manner. Several Ca2+ transport systems have evolved by which to accomplish this task. These mechanisms typically act together to maintain Ca2+ homeostasis, thereby preventing buildup of cytoplasmic Ca2+ which would be cytotoxic. There are two plasmalemmal active transport systems which directly regulate Ca2+ fluxes in many types of cells. The first, a Ca2+, Mg2+-ATPase, is an ATP-dependent pump of low capacity, but high affinity that extrudes Ca2+ unidirectionally from the cell (Chap. 8). The other, an Na,Ca antiporter, moves Ca2+ via a carrier mechanism controlled by transmembrane electrical and Na+ concentration gradients. Since Na,Ca exchange is completely reversible, transmembrane Ca2+ movement can occur in either direction, depending on cellular conditions which regulate carrier activity. These are the only two Ca2+ transport processes known to remove Ca2+ from the cell.

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Authors
  1. G. J. Kaczorowski
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  2. M. L. Garcia
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  3. V. F. King
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  4. R. S. Slaughter
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Editors and Affiliations

  1. Department of Physiology King’s College, University of London, Strand, London, WC2R 2LS, Great Britain

    Peter F. Baker (Professor Sc. D., F.R.S.) (Professor Sc. D., F.R.S.)

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Kaczorowski, G.J., Garcia, M.L., King, V.F., Slaughter, R.S. (1988). Development of Inhibitors of Sodium, Calcium Exchange. In: Baker, P.F. (eds) Calcium in Drug Actions. Handbook of Experimental Pharmacology, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71806-9_9

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  • DOI: https://doi.org/10.1007/978-3-642-71806-9_9

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