Skip to main content
SpringerLink
Log in

Hormonal Control of Extracellular Calcium

  • Chapter
Calcium in Drug Actions

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 83))

Abstract

Despite wide differences in calcium intake, plasma calcium is maintained with remarkable constancy. Approximately half of total plasma calcium is ionised and the remainder is largely bound to plasma albumin. Extracellular calcium concentration is more than 1000-fold greater than the critical intracellular concentration; a major change in the former would almost certainly be followed by gross disturbances in cellular metabolism, eventually leading to death. To prevent this, a set of interlocking hormonal mechanisms have evolved in vertebrates. These have been reviewed here with particular reference to the major clinical consequences of their disturbance and therapeutic approaches used for their correction.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM (1982) Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 298:240–244

    Article  PubMed  CAS  Google Scholar 

  • Amara SG, Arriza JL, Leff SE, Swanson LW, Evans RM, Rosenfeld MG (1985) Expression in brain of messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide. Science 229:1094–1097

    Article  PubMed  CAS  Google Scholar 

  • Arnaud CD, Goldsmith RS, Bordier PJ, Sizemore GW (1974) Influence of immunoheterogenaeity of circulating parathyroid hormone on results of radioimmunoassay of serum in man. Am J Med 56:785–793

    Article  PubMed  CAS  Google Scholar 

  • Aurbach GD, Chase LD (1976) Cyclic nucleotides and biochemical actions of parathyroid hormone and calcitonin. In: Greep RO, Astwood EB (eds) Handbook of physiology. Endocrinology. American Physiological Society, Washington DC, pp 353–381

    Google Scholar 

  • Avioli LV, Krane SM (1978) Metabolic bone disease, vol 2. Academic, New York

    Google Scholar 

  • Bevis PJR, MacIntyre I, Morris HR, Zaidi M (1986 a) On the presence of a potent vasodilator calcitonin gene-related peptide in rat plasma. J Physiol (Lond) 376:24

    Google Scholar 

  • Bevis PJR, MacIntyre I, Zaidi M (1986 b) Further evidence for the neural release of plasma calcitonin gene-related peptide. Br J Pharmacol 88:314

    Google Scholar 

  • Bevis PJR, Zaidi M, Lynch C, Beacham J, Chambers TJ, MacIntyre I (1986 c) Human beta-calcitonin gene related peptide inhibits osteoclastic bone resorption and lowers plasma calcium. Bone (in press)

    Google Scholar 

  • Boyle IT, Gray RW, DeLuca HF (1971) Regulation by calcium of in vivo synthesis of 1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol. Proc Natl Acad Sci USA 58:2131–2134

    Article  Google Scholar 

  • Brain SD, Williams TJ, Tippins JR, Morris HR, MacIntyre I (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 313:54–56

    Article  PubMed  CAS  Google Scholar 

  • Brain SD, MacIntyre I, Williams TJ (1986) A second form of human calcitonin gene-related peptide which is a potent vasodilator. Eur J Pharmacol 124:349–352

    Article  PubMed  CAS  Google Scholar 

  • Broadus AE, Goltzman D, Webbs AC, Kronenberg HM (1985) Messenger ribonucleic acid from tumors associated with humoral hypercalcemia of malignancy directs the synthesis of a secretory parathyroid hormone-like peptide. Endocrinology 117:1661–1666

    Article  PubMed  CAS  Google Scholar 

  • Canterbury JM, Reiss E (1972) Multiple immunoreactive molecular forms of parathyroid hormone in human serum. Proc Soc Exp Biol Med 140:1393–1398

    PubMed  CAS  Google Scholar 

  • Care AD (1970) The effects of pancreozymin and secretin on calcitonin release. Fed Proc 29:253

    Google Scholar 

  • Chambers TJ (1982) Pathobiology of the osteoclast. J Clin Pathol 38:214–252

    Google Scholar 

  • Chambers TJ, Moore A (1983) The sensitivity of isolated osteoclasts to morphological transformation by calcitonin. J Clin Endocrinol Metab 57:819–824

    Article  PubMed  CAS  Google Scholar 

  • Chambers TJ, Athanasou NA, Fuller K (1984) Effect of parathyroid hormone and calcitonin on the cytoplasmic spreading of isolated osteoclasts. J Endocrinol 102:281–286

    Article  PubMed  CAS  Google Scholar 

  • Chambers TJ, McSheehy PMJ, Thomson BM, Fuller K (1985 a) The effect of calcium-regulating hormones and prostaglandins on bone resorption by osteoclasts disaggregated from neonatal rabbit bones. Endocrinology 60:234–239

    Article  Google Scholar 

  • Chambers TJ, Fuller K, McSheehy PMJ, Pringle JAS (1985 b) The effect of calcium regulating hormones on bone resorption by isolated human osteoclastoma cells. J Pathol 145:297–305

    Article  PubMed  CAS  Google Scholar 

  • Chase LR, Aurbach GD (1967) Parathyroid function of the renal excretion of 3′,5′-adenylic acid. Proc Natl Acad Sci USA 58:518–525

    Article  PubMed  CAS  Google Scholar 

  • Chase LR, Aurbach GD (1968) Renal adenyl cyclase: anatomical separation of sites sensitive to parathyroid hormone and vasopressin. Science 159:545–547

    Article  PubMed  CAS  Google Scholar 

  • Cooper CW, Schwesinger WH, Mahgoub AM, Ontjes DA (1971) Thyrocalcitonin stimulation of secretion by pentagastrin. Science 172:1238–1240

    Article  PubMed  CAS  Google Scholar 

  • Copp DH, Cameron EC, Cheney BA, Davidson AGF, Henze KG (1962) Evidence for calcitonin — a new hormone from the parathyroid that lowers blood calcium. Endocrinology 70:638–649

    Article  PubMed  CAS  Google Scholar 

  • Crawford A, Evans DB, Skjodt H, Beresford JN, MacIntyre I, Russell RGG (1986) Effect of human calcitonin gene-related peptide on human bone-derived cells in culture. Bone 7:157–158

    Article  Google Scholar 

  • Fenwick JC (1982) Some evidence concerning the nature of the hypocalcemic factor in the Stannius corpuscles. In: Oguro C, Pang PKT (eds) Comparative endocrinology of calcium regulation. Japan Scientific Societies Press, Tokyo, pp 167–172

    Google Scholar 

  • Fischer JA, Binswanger U, Dietrich FM (1974) Human parathyroid hormone: immunological characterization of antibodies against a glandular extract and the synthetic amino-terminal fragments 1–12 and their use in the determination of immunoreactive hormone in human sera. J Clin Invest 54:1382–1394

    Article  PubMed  CAS  Google Scholar 

  • Fontaine M (1964) Corpuscles de Stannius et régulation ionique (Ca, K, Na) du milieu interieur de l’anguille (Anguilla anguilla L.). CR Seances Acad Sci [III] 259:875–878

    CAS  Google Scholar 

  • Foster GV, Baghdiantz A, Kumar MA, Slack E, Soliman HA, MacIntyre I (1964) Thyroid origin of calcitonin. Nature 202:1303–1305

    Article  PubMed  CAS  Google Scholar 

  • Fraser DR (1980) Regulation of the metabolism of vitamin D. Physiol Rev 60:551–607

    PubMed  CAS  Google Scholar 

  • Freake HC, MacIntyre I (1982) Specific binding of 1,25-dihydroxycholecalciferol in human medullary thyroid carcinoma. Biochem J 206:181–184

    PubMed  CAS  Google Scholar 

  • Friedman J, Raisz LG (1965) Thyrocalcitonin inhibitor of bone resorption in tissue culture. Science 150:1465–1467

    Article  PubMed  CAS  Google Scholar 

  • Galan Galan F, Perez Cano R, Rodriguez R et al. (1985) Deficit de calcitonia en la osteoporosis posmenopausica. Med Clin (Barc) 85:221

    CAS  Google Scholar 

  • Galante L, Colston KW, MacAuley SJ, MacIntyre I (1972) Effect of calcitonin on vitamin D metabolism. Nature 238:271–273

    Article  PubMed  CAS  Google Scholar 

  • Garabedian M, Holick MF, DeLuca HF, Boyle IT (1972) Control of 25-hydroxycholecal-ciferol metabolism by parathyroid glands. Proc Natl Acad Sci USA 69:1673–1676

    Article  PubMed  CAS  Google Scholar 

  • Girgis SI, Macdonald DWR, Stevenson JC, Bevis PJR, Lynch C, Wimalawansa SJ, Self CH, Morris HR, MacIntyre I (1985) Calcitonin gene-related peptide: potent vasodilator and major product of calcitonin gene. Lancet 2:14–16

    Article  PubMed  CAS  Google Scholar 

  • Goldsmith RS, Furszyfer J, Johnson WJ, Fournier AE, Sizemore GW, Arnaud CD (1973) Etiology of hyperparathyroidism and bone disease during chronic hemodialysis. III. Evaluation of parathyroid suppressibility. J Clin Invest 52:173–180

    Article  PubMed  CAS  Google Scholar 

  • Goltzman D, Mitchell J (1985) Interaction of calcitonin and calcitonin gene-related peptide at receptor sites in target tissues. Science 227:1343–1345

    Article  PubMed  CAS  Google Scholar 

  • Habener JF, Rosenblatt M, Potts JT Jr (1984) Parathyroid hormone: biochemical aspects of biosynthesis, secretion, action and metabolism. Physiol Rev 64:985–1053

    PubMed  CAS  Google Scholar 

  • Hausslet MR, Bayling DJ, Hughes MR, Brumbaugh PF, Wergedal JE, Shen FH, Nielsen RL, Counts SJ, Bursac KM, McCain TA (1976) The assay of 1α,25-dihydroxyvitamin D3: physiologic and pathologic modulation of circulating hormone levels. Clin Endocrinol (Oxf) 5:151S–165S

    Article  Google Scholar 

  • Heinrich G, Kronenberg HM, Potts JT Jr, Habener JF (1984) Gene encoding parathyroid hormone. Nucleotide sequence of the rat gene and deduced aminoacid sequence of rat preproparathyroid hormone. J Biol Chem 259:3320–3329

    PubMed  CAS  Google Scholar 

  • Hillyard CJ, Stevenson JC, MacIntyre I (1978) Relative deficiency of plasma-calcitonin in normal women. Lancet 1:961–962

    Article  PubMed  CAS  Google Scholar 

  • Hillyard CJ, Myers C, Abeyasekera G, Stevenson JC, Craig RK, MacIntyre I (1983) Katacalcin: a new plasma calcium-lowering hormone. Lancet 1:846–848

    Article  PubMed  CAS  Google Scholar 

  • Hirsch PF, Gauthier GF, Munson PL (1963) Thyroid hypocalcaemic principle and recurrent laryngeal nerve injury as factors affecting the response to parathyroidectomy in rats. Endocrinology 73:244–252

    Article  PubMed  CAS  Google Scholar 

  • Hoppener JWM, Steenbergh PH, Bakker E, Pearson PL, Geurts van Kessel AHM, Jansz HS, Lipps CJM (1984) Localization of the polymorphic human calcitonin gene on chromosome 11. Hum Genet 66:309–312

    Article  PubMed  CAS  Google Scholar 

  • Hoppener JWM, Steenbergh PH, Geurts van Kessel AHM, Baylin SB, Nelkin BD, Jansz HS, Lips CJM (1985) The second human calcitonin/CGRP gene is located on chromosome 11. Hum Genet 70:259–263

    Article  PubMed  CAS  Google Scholar 

  • Horiuchi N, Suda T, Sasaki S, Takahashi H, Shimazawa E, Ogata E (1976) Absence of regulatory effects of 1,25-dihydroxyvitamin D3 on 25-hydroxyvitamin D metabolism in rats constantly infused with parathyroid hormone. Biochem Biophys Res Commun 73:869–875

    Article  PubMed  CAS  Google Scholar 

  • Kaminsky NI, Broadus AE, Hardman JG, Jones DJ Jr, Ball JH, Sutherland EW, Liddle GW (1970) Effects of parathyroid hormone plasma and urinary adenosine 3′,5′-monophosphate in man. J Clin Invest 49:2387–2395

    Article  PubMed  CAS  Google Scholar 

  • Kawashima H, Torikai S, Kurokawa K (1981) Calcitonin selectively stimulates 25-hydroxyvitamin D3-1-hydroxylase in proximal straight tubule of rat kidney. Nature 291:327–319

    Article  PubMed  CAS  Google Scholar 

  • Keutman HT, Sauer RM, Hendy GN, O’Riordan JLH, Potts JT Jr (1978) Complete amino acid sequence of human parathyroid hormone. Biochemistry 17:5723–5729

    Article  Google Scholar 

  • Kittur SD, Hoppener JWM, Antonaratis SE, Daniels JDJ, Meyers DA, Maestri NE, Jansen M, Kormeluk RG, Neltin BD, Kazazian HH (1985) Linkage map of the short arm of human chromosome 11: location of the genes for catalase, calcitonin and insulin-like growth factor II. Proc Natl Acad Sci USA 82:5064–5067

    Article  PubMed  CAS  Google Scholar 

  • Kumar MA, Foster GV, MacIntyre I (1963) Further evidence for calcitonin, a rapid-acting hormone which lowers plasma calcium. Lancet 2:480–482

    Article  PubMed  CAS  Google Scholar 

  • Lafeber F, Hermann-Erlee MPM, van der Meer JM, Flick G, Verbost P, Wendelaar Bonga SE (1984) Effects of products released by trout corpuscles of Stannius on calcium mobilization and cAMP formation of mouse calvaria in vitro and on plasma calcium in eels. Calcif Tissue Int [Suppl 2] 3:50

    Google Scholar 

  • Larkins RG, MacAuley SJ, Colston KW, Evans IMA, Galante LS, MacIntyre I (1973) Regulation of vitamin D metabolism without parathyroid hormone. Lancet 2:289–291

    Article  PubMed  CAS  Google Scholar 

  • Lee Y, Kawai Y, Shiosaka S, Takami K, Kiyama H, Hillyard CJ, Girgis S, MacIntyre I, Emson PC, Tohyama M (1985) Coexistence of calcitonin gene-related peptide and substance P-like peptide in single cells of the trigeminal ganglion of the rat: immunohistochemical analysis. Brain Res 330:194–196

    Article  PubMed  CAS  Google Scholar 

  • Lopez E, Tisserand-Jochem EM, Eyquem A, Milet C, Hillyard C, Lallier F, Vidal B, MacIntyre I (1984 a) Immunocytochemical detection in eel corpuscles of Stannius of a mammalian parathyroid-like hormone. Gen Comp Endocrinol 53:28–36

    Article  PubMed  CAS  Google Scholar 

  • Lopez E, Tisserand-Jochem EM, Vidal B, Milet C, Lallier F, MacIntyre I (1984 b) Les corpuscles de Stannius sont-ils les glandes parathyroides des poissons téléostéens? Arguments ultrastructuraux, cytologiques et immunocytochimiques. CR Seances Acad Sci [III] 298:359–364

    CAS  Google Scholar 

  • Lwowski ES (1978) The corpuscles of Stannius and calcified tissues in the eel, Anguilla rostrata L. Comp Biochem Physiol 59A:183–187

    Article  Google Scholar 

  • Ma SWY, Copp DH (1978) Purification, properties and action of a glycopeptide from the corpuscles of Stannius which affects calcium metabolism in the teleost. In: Gaillard PJ, Boer HH (eds) Comparative endocrinology. Elsevier/North Holland, Amsterdam, pp 283–286

    Google Scholar 

  • MacIntyre I (1984) The calcitonin gene peptide family and the central nervous system. In: Labrie F, Proulx L (eds) Proceedings of the 7th International Congress of Endocrinology, Quebec, Canada, July 1984. Excerpta Medica, Amsterdam, pp 930–933

    Google Scholar 

  • MacIntyre I (1987) Calcitonin gene peptides. In: De Groot L (ed) Endocrinology, 2nd edn. Grune and Stratton, Orlando

    Google Scholar 

  • MacIntyre I, Colston KW, Szelke M, Spanos E (1978) A survey of hormonal factors that control calcium metabolism. In: Scarpa A, Carafoli E (eds) Calcium transport and cell function. Ann NY Acad Sci 307:345–355

    Google Scholar 

  • MacIntyre I, Arnett TR, Brown DJ, Galan Galan F, Girgis SI, Rogers RM, Spanos E, Stevenson JC, Bone Q (1979) The interrelation of the calcium regulating hormones: some recent findings. In: MacIntyre I, Szelke M (eds) Molecular endocrinology. Elsevier/North Holland, Amsterdam, pp 193–201

    Google Scholar 

  • MacIntyre I, Milet C, Arnett TR, Coghlan JP, Hillyard CJ, Girgis S, Martelly E, Niall HD, Lopez E (1981) The eel corpuscles of Stannius secrete a molecule resembling mammalian parathyroid hormone (abstr 165). 63rd Annual Meeting of the Endocrine Society USA (1981)

    Google Scholar 

  • MacIntyre I, Hillyard CJ, Murphy PK, Reynolds JJ, Gaines Das RE, Craig RK (1982) A second plasma calcium lowering peptide from the human calcitonin precursor. Nature 300:460–462

    Article  PubMed  CAS  Google Scholar 

  • MacIntyre I, Hillyard CJ, Reynolds JJ, Gaines Das RE, Craig RK (1984) A second plasma calcium lowering peptide from the human calcitonin precursor: a re-evaluation. Nature 308:84

    PubMed  CAS  Google Scholar 

  • MacIntyre I, Alerizaki M, Bevis PJR, Zaidi M (1987) Calcitonin and peptides from the calcitonin gene. Clin Orthop and Rel Res 217:45–54

    CAS  Google Scholar 

  • McEwan J, Chierchia S, Davies G, Stevenson JC, Brown M, Maseri A, MacIntyre I (1985) Coronary vasodilatation by calcitonin gene-related peptide. Br Heart J 54:643–645

    Google Scholar 

  • McSheehy PMJ, Chambers TJ (1986 a) Osteoblastic cells mediate osteoclastic responsiveness to PTH. Endocrinology 118:824–827

    Article  PubMed  CAS  Google Scholar 

  • McSheehy PMJ, Chambers TJ (1986 b) Osteoblast-like cells in the presence of parathyroid hormone release soluble factor that stimulates osteoblastic bone resorption. Endocrinology 119 (in press)

    Google Scholar 

  • Milet C (1986) PhD Dissertation, University of Paris (in press)

    Google Scholar 

  • Milet C, Lopez E, Chartier MM, Martelly E, Lallier F, Vidal B (1979 a) A new calcium regulating hormone from the corpuscles of Stannius. In: MacIntyre I, Szelke M (eds) Molecular endocrinology. Elsevier/North Holland, Amsterdam, pp 341–348

    Google Scholar 

  • Milet C, Peignoux-Deville J, Martelly E (1979 b) Gill calcium fluxes in the eel, Anguilla anguilla L. Effects of Stannius corpuscles and ultimobranchial body. Comp Biochem Physiol 63A:63–70

    Article  CAS  Google Scholar 

  • Milet C, Hillyard CJ, Martelly E, Girgis S, MacIntyre I, Lopez E (1980) Similitudes structurales entre l’hormone hypocalcémiante des corpuscles de Stannius (PCS) de l’anguille (Anguilla anguilla L.) et l’hormone parathyroidienne mammalienne. CR Seances Acad Sci [III] 291:977–980

    CAS  Google Scholar 

  • Milhaud G, Perault A-M, Moukhtar MA (1965) Etude du mécanisme de l’action hypocalcémiante de la thyrocalcitonine. CR Seances Acad Sci [III] 261:813–816

    CAS  Google Scholar 

  • Morimoto S, Tsuji M, Okada Y, Onishi T, Kumahara Y (1980) The effect of oestrogens on human calcitonin secretion after calcium infusion in elderly female subjects. Clin Endocrinol (Oxf) 13:135–143

    Article  CAS  Google Scholar 

  • Morris HR, Panico M, Etienne T, Tippins J, Girgis SI, MacIntyre I (1984) Isolation and characterisation of human calcitonin gene-related peptide. Nature 308:746–748

    Article  PubMed  CAS  Google Scholar 

  • Nagant de Deuxchaisnes C, Rombouts-Lindemans C, Huaux JP, Devogelaer JP, Malghem J, Maldague B (1979) Roentgenologic evaluation of the action of the diphosphonate EHDP and of combined therapy (EHDP and calcitonin) in Paget’s disease of bone. In: MacIntyre I, Szelke M (eds) Molecular endocrinology. Elsevier/North Holland, Amsterdam, pp 405–433

    Google Scholar 

  • Parsons JA (1976) Parathyroid physiology and the skeleton. In: Bourne GH (ed) The biochemistry and physiology of bone. Academic, New York, pp 159–225

    Google Scholar 

  • Parsons JA, Zanelli JM (1980) Physiological role of the parathyroid glands. In: Kuhlencordt F, Bartelheimer H (eds) Klinische Osteologie. Springer, Berlin Heidelberg New York, pp 135–172 (Handbuch der inneren Medizin, vol 6/1)

    Google Scholar 

  • Robinson CJ, Martin TJ, Matthews EW, MacIntyre I (1967) Mode of action of thyrocalcitonin. J Endocrinol 39:71–79

    Article  PubMed  CAS  Google Scholar 

  • Rosenblatt M, Beaudette NV, Fasman GD (1980) Conformational studies of the synthetic precursor-specific region of pre-proparathyroid hormone. Proc Natl Acad Sci USA 77:3983–3987

    Article  PubMed  CAS  Google Scholar 

  • Rosenfeld MG, Lin CR, Amara SG, Stolarsky L, Roos BA, Ong ES, Evans RM (1982) Calcitonin mRNA polymorphism: peptide switching associated with alternative RNA splicing events. Proc Natl Acad Sci USA 79:1717–1721

    Article  PubMed  CAS  Google Scholar 

  • Rosenfeld MG, Mermod J-J, Amara SG, Swanson LW, Sawchenko PE, Rivier J, Vale WW, Evans RM (1983) Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 304:129–135

    Article  PubMed  CAS  Google Scholar 

  • Stannius FH (1839) Ueber Nebennieren bei Knochenfischen. Arch Anat Physiol 91–101

    Google Scholar 

  • Steenbergh PH, Hoppener JWM, Zandberg J, Lips CJM, Jansz HS (1985) A second human calcitonin/CGRP gene. FEBS Lett 183:403–407

    Article  PubMed  CAS  Google Scholar 

  • Stevenson JC, Hillyard CJ, MacIntyre I, Cooper H, Whitehead MI (1979) Physiological role for calcitonin: protection for the maternal skeleton. Lancet 2:769–770

    Article  PubMed  CAS  Google Scholar 

  • Stevenson JC, Abeyasekera G, Hillyard CJ, Phang KG, MacIntyre I, Campbell S, Townsend PT, Young O, Whitehead MI (1981) Calcitonin and the calcium-regulating hormones in postmenopausal women: effect of oestrogens. Lancet 1:693–695

    Article  PubMed  CAS  Google Scholar 

  • Stevenson JC, MacIntyre I, Whitehead MI (1982) Impaired calcitonin secretion after premature menopause. Calcif Tissue Int [Suppl 1] 34:821

    Google Scholar 

  • Stevenson JC, Abeyasekera G, Hillyard CJ, Phang KG, MacIntyre I, Campbell S, Lane E, Townsend PT, Young O, Whitehead MI (1983) Regulation of calcium-regulating hormones by exogenous sex steroids in early postmenopause. Eur J Clin Invest 13:481–487

    Article  PubMed  CAS  Google Scholar 

  • Struthers AD, Brown MJ, Macdonald DWR, Beacham JL, Stevenson JC, Morris HR, MacIntyre I (1985) Human CGRP: the most potent endogenous vasodilator in man. Clin Sci 70:389–393

    Google Scholar 

  • Suda T, Abe E, Miyaura C et al. (1983) Does vitamin D have a specific role in cell growth and differentiation? In: Cohn DV, Fujita T, Potts JT Jr, Talmage RV (eds) Endocrine control of bone and calcium metabolism, vol 8A. Excerpta Medica, Amsterdam, pp 308–315

    Google Scholar 

  • Taggert HMc, Chesnut CH, Ivey JL, Baylink DJ, Sisom K, Huber MB, Roos BA (1982) Deficient calcitonin response to calcium stimulation in postmenopausal osteoporosis. Lancet 1:475–478

    Article  Google Scholar 

  • Tippins JR, Morris HR, Panico M, Etienne T, Bevis P, Girgis S, MacIntyre I, Azria M, Attinger M (1984) The myotropic and plasma-calcium modulating effects of calcitonin gene-related peptide (CGRP). Neuropeptides 4:425–434

    Article  PubMed  CAS  Google Scholar 

  • Torring O, Bucht E, Sjöberg HE (1984) Can a relative calcitonin deficiency contribute to the development of postmenopausal osteoporosis? In: Christiansen C, Arnaud CD, Nordin BEC, Parfitt AM, Peck WA, Riggs BL (eds) Osteoporosis. Glostrup Hospital, Glostrup, pp 393–395

    Google Scholar 

  • Tschopp FA, Tobler PH, Fischer JA (1984) Calcitonin gene-related peptide in the human thyroid pituitary and brain. Mol Cell Endocrinol 36:53–57

    Article  PubMed  CAS  Google Scholar 

  • Tschopp FA, Henke H, Petermann JB, Tobler TH, Janzer R, Hokfelt T, Lundberg JM, Cuells C, Fischer JA (1985) Calcitonin gene related peptide and its binding site in the human central nervous system and pituitary. Proc Natl Acad Sci USA 82:248–252

    Article  PubMed  CAS  Google Scholar 

  • Wanaka A, Matsuyama T, Yoneda S, Kimura K, Kamada T, MacIntyre I, Emson PC, Tohyama M (1987) Origins and distribution of calcitonin gene-related peptide-containing nerves in the wall of the cerebral arteries of the guinea pig with special reference to the coexistence with substance P. Brain Res (in press)

    Google Scholar 

  • Zaidi M, Bevis PJR, Abeyasekera G, Girgis SI, MacIntyre I (1985 a) Studies on circulating calcitonin gene-related peptide in the rat. J Endocrinol 107:43

    Google Scholar 

  • Zaidi M, Bevis PJR, Girgis SI, Lynch C, Stevenson JC, MacIntyre I (1985 b) Circulating CGRP comes from the perivascular nerves. Eur J Pharmacol 117:283–284

    Article  PubMed  CAS  Google Scholar 

  • Zaidi M, Bevis PJR, Abeyasekera G, Girgis SI, Wimalawansa SJ, Morris HR, MacIntyre I (1986 a) The origin of calcitonin gene-related peptide in the rat. J Endocrinol 110:185–190

    Article  PubMed  CAS  Google Scholar 

  • Zaidi M, Bevis PJR, Diez Guerra J, Lynch C, Wimalawansa SJ, Emson PC, MacIntyre I (1986 b) Circulation of neurally derived calcitonin gene related peptide (abstr). Neuroendocrinology 74 (Special Issue)

    Google Scholar 

  • Zaidi M, Bevis PJR, MacIntyre I (1986 c) The dual origin of plasma calcitonin gene related peptide (abstr). 68th Annual Meeting of the Endocrine Society

    Google Scholar 

  • Zaidi M, Bevis PJR, Lynch C, McSheehy PMJ, Chambers TJ, MacIntyre I (1986d) The calcitonin-like effect of α and ß human CGRP is mediated via direct osteoclastic inhibition. J Bone Min Res 1:357

    Google Scholar 

  • Zaidi M, Fuller K, Bevis PJR, Gaines Das RE, Chambers TJ, MacIntyre I (1987 a) Calcitonin gene related peptide inhibits osteoclastic bone resorption: a comparative study. Calcif Tissue Int 40:149–154

    Article  PubMed  CAS  Google Scholar 

  • Zaidi M, Chambers TJ, Gaines Das RE, Morris HR, MacIntyre I (1987 b) A direct effect of human calcitonin gene related peptide on isolated osteoclasts. J Endocrinol 115 (in press)

    Google Scholar 

References added in proof

  • Alevizaki M, Shiraishi A, Rassool FV, Ferrier GJM, MacIntyre I, Legon S (1986) The calcitonin-like sequence of the-CGRP gene. FEBS Lett 206:47–41

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. I. MacIntyre
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Zaidi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Milet
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. J. R. Bevis
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Physiology King’s College, University of London, Strand, London, WC2R 2LS, Great Britain

    Peter F. Baker (Professor Sc. D., F.R.S.) (Professor Sc. D., F.R.S.)

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

MacIntyre, I., Zaidi, M., Milet, C., Bevis, P.J.R. (1988). Hormonal Control of Extracellular Calcium. In: Baker, P.F. (eds) Calcium in Drug Actions. Handbook of Experimental Pharmacology, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71806-9_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71806-9_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71808-3

  • Online ISBN: 978-3-642-71806-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation