Skip to main content
SpringerLink
Log in

Pharmacology of Calcium Metabolism in Smooth Muscle

  • Chapter
Calcium in Drug Actions

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 83))

Abstract

Calcium may be considered as the ultimate intracellular messenger of the signals received at the level of smooth muscle pericellular membrane to produce a change in the active tone. The calcium responsible for the increase in free cytoplasmic levels is potentially available from the intracellular space and also from several compartments having various affinities for calcium. Several cellular mechanisms maintain the calcium gradient across the plasmalemmal membrane. They are associated with the plasma membrane itself and with intracellular organelles. Differences between muscles are to some extent due to differences in the importance and the properties of the different mechanisms operating at rest and during activation. Pharmacologic agents influence calcium movements by acting on those mechanisms responsible for calcium homeostasis at the cellular level (Table 1). Understanding of the mode of action of those agents requires a proper analysis of the mechanisms of this calcium homeostasis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alosachie I, Godfraind T (1986) Role of cyclic GMP in the modulation by endothelium of the adrenolytic action of prazosin in rat isolated aorta. Br J Pharmacol 80:525–532

    Google Scholar 

  • Baker PF, Blaustein MP, Hodgkin AL, Steinhard RA (1969) The influence of Ca on Na efflux in squid axons. J Physiol (Lond) 200:431–458

    CAS  Google Scholar 

  • Batra S (1985) Characterization of [3H]-nitrendipine binding to uterine smooth muscle plasma membrane and its relevance to inhibition of calcium entry. Br J Pharmacol 85:767–774

    PubMed  CAS  Google Scholar 

  • Bolger GT, Gengo PJ, Luchowski EM, Siegel H, Toggle DJ, Janis RA (1982) High affinity binding of a calcium channel antagonist to smooth and cardiac muscle. Biochem Biophys Res Commun 104:1604–1609

    Article  PubMed  CAS  Google Scholar 

  • Bolger GT, Gengo P, Klockowski R, Luchowski E, Siegel H, Janis RA, Triggle AM, Triggle DJ (1983) Characterization of binding of the Ca++ channel antagonist, [3H]nitrendipine, to guinea-pig ileal smooth muscle. J Pharmacol Exp Ther 225:291–309

    PubMed  CAS  Google Scholar 

  • Bolton TB (1979) Mechanisms of action of transmitters and other substances on smooth muscle. Physiol Rev 59:606–718

    PubMed  CAS  Google Scholar 

  • Brading AF (1981) Ionic distribution and mechanism of transmembrane ion movements in smooth muscle. In: Bülbring EE, Brading AF, Jones AW, Tomita T (eds) Smooth muscle. Arnold, London, pp 65–92

    Google Scholar 

  • Broekaert A, Godfraind T (1979) A comparison of the inhibitory effect of cinnarizine and papaverine on the noradrenaline and calcium-evoked contraction of isolated rabbit aorta and mesenteric arteries. Eur J Pharmacol 53:281–288

    Article  PubMed  CAS  Google Scholar 

  • Caroni P, Carafoli E (1983) The regulation of the Na+-Ca2+ exchanger of heart sarcolemma. Eur J Biochem 132:451–460

    Article  PubMed  CAS  Google Scholar 

  • Caroni P, Reinlib L, Carafoli E (1980) Charge movements during the Na+-Ca2+ exchange in heart sarcolemmal vesicles. Proc Natl Acad Sci (USA) 77:6354–6358

    Article  CAS  Google Scholar 

  • Casteels R, van Breemen C (1975) Active and passive Ca2+ fluxes across cell membranes of the guinea-pig taenia coli. Pflügers Arch 359:197–207

    Article  PubMed  CAS  Google Scholar 

  • Cauvin C, Saida K, van Breemen C (1982) Effects of Ca antagonists on Ca fluxes in resistance vessels. J Cardiovasc Pharmacol 4:S287–290

    Article  PubMed  Google Scholar 

  • De Pover A, Matlib MA, Lee SW, Dube GP, Grupp IL, Grupp G, Schwartz A (1982) Specific binding [3H] nitrendipine to membranes from coronary arteries and heart in relation to pharmacological effects. Paradoxical stimulation by diltiazem. Biochem Biophys Res Commun 108:110–117

    Article  Google Scholar 

  • Egleme C, Godfraind T, Miller RC (1984) Enhanced responsiveness of rat isolated aorta to Clonidine after removal of the endothelial cell. Br J Pharmacol 81:16–18

    PubMed  CAS  Google Scholar 

  • Fabiato A, Fabiato F (1979) Calcium and cardiac excitation contraction coupling. Ann Rev Physiol 41:473–484

    Article  CAS  Google Scholar 

  • Fleckenstein A (1973) Calcium antagonism in heart and smooth muscle. Wiley, New York

    Google Scholar 

  • Furchgott RF (1984) The role of endothelium in the responses of vascular smooth muscle to drugs. Ann Rev Pharmacol Toxicol 24:175–197

    Article  CAS  Google Scholar 

  • Godfraind T (1976) Calcium exchange in vascular smooth muscle, action of noradrenaline and lanthanum. J Physiol (Lond) 260:21–35

    CAS  Google Scholar 

  • Godfraind T (1983) Actions of nifedipine on calcium fluxes and contraction in isolated rat arteries. J Pharmacol Exp Ther 224:443–450

    PubMed  CAS  Google Scholar 

  • Godfraind T (1985) Cellular and subcellular approaches to the mechanism of action of calcium antagonists. In: Rubin RP, Weiss GB, Putney JW (eds) Calcium in biological systems. Plenum, New York, pp 411–421

    Chapter  Google Scholar 

  • Godfraind T (1986 a) Calcium entry blockade and excitation contraction coupling in the cardiovascular systems (with an attempt of pharmacological classification). Acta Pharmacol Toxicol 58 (Suppl 2): 5–30

    Article  CAS  Google Scholar 

  • Godfraind T (1986 b) EDRF and cyclic GMP control gating of receptor-operated calcium channels in vascular smooth muscle. Eur J Pharmacol 126:341–343

    Article  PubMed  CAS  Google Scholar 

  • Godfraind T, Dieu D (1981) The inhibition by fluanrizine on the norepinephrine evoked contraction and calcium influx in rat aorta and mesenteric arteries. J Pharmacol Exp Ther 217:510–515

    PubMed  CAS  Google Scholar 

  • Godfraind T, Kaba A (1969) Blockade or reversal of contraction induced by calcium and adrenaline in depolarized arterial smooth muscle. Br J Pharmacol 36:549–560

    PubMed  CAS  Google Scholar 

  • Godfraind T, Miller RC (1983) Specificity of action of Ca+ entry blockers. A comparison of their actions in rat arteries and in human coronary arteries. Circ Res 52 (Suppl 1):81–91

    CAS  Google Scholar 

  • Godfraind T, Polster P (1968) Etude comparative de médicaments inhibant la réponse contractile de vaisseaux isolés d’origine humaine et animale. Thérapie 23:1209–1220

    PubMed  CAS  Google Scholar 

  • Godfraind T, Wibo M (1985) Subcellular localization of [3H]-nitrendipine binding sites in guinea-pig ileal smooth muscle. Br J Pharmacol 85:335–340

    PubMed  CAS  Google Scholar 

  • Godfraind T, Kaba A, Polster P (1968) Differences in sensitivity of arterial smooth muscle to inhibition of their contractile response to depolarization by potassium. Arch Int Pharmacodyn Ther 172:235–239

    PubMed  CAS  Google Scholar 

  • Goodfraind T, Finet M, Socrates Lima J, Miller R (1984) Contractile activity of human coronary arteries and human myocardium in vitro and their sensitivity to calcium entry blockade by nifedipine. J Pharmacol Exp Ther 230:514–518

    Google Scholar 

  • Godfraind T, Egleme C, Alosachie I (1985 a) Role of endothelium in the contractile response of rat aorta to alpha-adrenergic agonists. Clin Sci 68:65s–71s

    PubMed  CAS  Google Scholar 

  • Godfraind T, Egleme C, Wibo M (1985 b) Effects of dihydropyridines on human and animal isolated vessels. In: Fleckenstein A, Breemen C van, Gross R, Hoffmeister F (eds) Cardiovascular effects of dihydropyridine-type calcium antagonists and agonists. Springer, Berlin Heidelberg New York Tokyo, pp 309–325 (Bayer symposium, vol 9)

    Chapter  Google Scholar 

  • Godfraind T, Miller RC, Wibo M (1986) Calcium antagonism and calcium entry blockade. Pharmacol Rev 38:321–416

    PubMed  CAS  Google Scholar 

  • Godfraind-De Becker A, Godfraind T (1980) Calcium transport system: a comparative study in different cells. Int Rev Cytol 67:141–170

    Article  PubMed  CAS  Google Scholar 

  • Grover AK, Oakes PJ (1985) Calcium channel antagonist binding and pharmacology in rat uterine smooth muscle. Life Sci 37:2187–2192

    Article  PubMed  CAS  Google Scholar 

  • Hidaka H, Hartshorne DJ (1985) Calmodulin antagonists and cellular physiology. Academic, Orlando, p 543

    Google Scholar 

  • Hirata M, Itoh T, Kuriyama H (1981) Effects of external cations on calcium efflux from single cells of guinea-pig taenia coli and porcine coronary artery. J Physiol (Lond) 310:321–336

    CAS  Google Scholar 

  • Jim K, Harris A, Rosenberger LB, Triggle DJ (1981) Stereoselective and non-stereoselective effects of D 600 (methoxyverapamil) in smooth muscle preparations. Eur J Pharmacol 76:67–72

    Article  PubMed  CAS  Google Scholar 

  • Lincoln TM (1983) Effects of nitroprusside and 8-bromo-cyclic GMP on the contractile activity of the rat aorta. J Pharmacol Exp Ther 224:100–107

    PubMed  CAS  Google Scholar 

  • Meisheri KD, van Breemen C (1982) Effects of beta-adrenergic stimulation on calcium movements in rabbit aortic smooth muscle: relation with cyclic AMP. J Physiol (Lond) 331:429–441

    CAS  Google Scholar 

  • Meisheri KD, Hwang O, van Breemen C (1981) Evidence for two separate Ca2+ pathways in smooth muscle-plasmalemma. J Membr Biol 59:19–25

    Article  PubMed  CAS  Google Scholar 

  • Morel N, Godfraind T (1982) Na-Ca exchange in heart and smooth muscle microsomes. Arch Int Pharmacodyn Ther 258:319–321

    PubMed  CAS  Google Scholar 

  • Morel N, Godfraind T (1984) Sodium/Calcium exchange in smooth-muscle microsomal fractions. Biochem J 218:421–427

    PubMed  CAS  Google Scholar 

  • Morel N, Wibo M, Godfraind T (1981) A calmodulin-stimulated Ca2+ pump in rat aorta plasma membranes. Biochim Biophys Acta 644:82–88

    Article  PubMed  CAS  Google Scholar 

  • Philipson KD, Nishimoto AY (1980) Na+-Ca2+ exchange is affected by membrane potential in cardiac sarcolemmal vesicles. J Biol Chem 255:6880–6882

    PubMed  CAS  Google Scholar 

  • Pitts BJ (1979) Stoichiometry of sodium-calcium exchange in cardiac sarcolemmal vesicles. J Biol Chem 254:6232–6235

    PubMed  CAS  Google Scholar 

  • Reeves JP, Sutko JL (1979) Sodium-calcium ion exchange in cardiac membrane vesicles. Proc Natl Acad Sci (USA) 76:590–594

    Article  CAS  Google Scholar 

  • Reuter H (1974) Exchange of calcium ions in the mammalian myocardium. Mechanisms and physiological significance. Circ Res 34:599–609

    PubMed  Google Scholar 

  • Reuter H (1982) Na-Ca countertransport in cardiac muscle. In: Martonosi A (ed) Membrane and transport, vol 1. Plenum, New York, pp 623–631

    Google Scholar 

  • Saida K, van Breemen C (1983) Mechanism of Ca2+ antagonist-induced vasodilation. Intracellular actions. Circ Res 52:137–142

    PubMed  CAS  Google Scholar 

  • Schatzmann HJ, Vincenzi FF (1969) Calcium movements across the membrane of human red cells. J Physiol (Lond) 201:369

    CAS  Google Scholar 

  • Schramm M, Thomas G, Towart R, Franckowiak G (1983) Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels. Nature 303:535–537

    Article  PubMed  CAS  Google Scholar 

  • Somlyo AV, Bond M, Somloy AP, Scarpa A (1985) Inositol trisphosphate-induced calcium release and contraction in vascular smooth muscle. Proc Natl Acad Sci USA 82:5231

    Article  PubMed  CAS  Google Scholar 

  • Suematsu E, Hirata M, Hashimoto T, Kuriyama H (1984) Inositol 1,4,5-trisphosphate releases Ca2+ from intracellular store sites in skinned single cells of porcine coronary artery. Biochem Biophys Res Commun 120:481

    Article  PubMed  CAS  Google Scholar 

  • Triggle CR, Agrawal DK, Bolger GT, Daniel EE, Kwan CY, Luchowski EM, Triggle DJ (1982) Calcium channel antagonist binding to isolated vascular smooth muscle membranes. Can J Physiol Pharmacol 60:1738–1741

    Article  PubMed  CAS  Google Scholar 

  • Van Nueten JM (1982) Selectivity of calcium entry blockers. In: Godfraind T, Albertini A, Paoletti R (eds) Calcium modulators. Elsevier, Amsterdam, pp 199–208

    Google Scholar 

  • Venter JC, Fraser CM, Schaber JS, Jung CY, Bolger S, Triggle DJ (1983) Molecular properties of the slow inward calcium channel. Molecular weight determinations by radiation inactivation and covalent affinity labeling. J Biol Chem 258:9344–9348

    PubMed  CAS  Google Scholar 

  • Wibo M, Morel N, Godfraind T (1981) Differentiation of Ca2+ pumps linked to plasma membrane and endoplasmic reticulum in the microsomal fraction from intestinal smooth muscle. Biochim Biophys Acta 649:651–660

    Article  PubMed  CAS  Google Scholar 

  • Williams JA (1980) Regulation of pancreatic acinar cell function by intracellular calcium. Am J Physiol 238:G269–G279

    PubMed  CAS  Google Scholar 

  • Winquist RJ (1984) Modulators of intracellular calcium. Drug Dev Res 4:241–256

    Article  CAS  Google Scholar 

Download references

Authors
  1. T. Godfraind
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Physiology King’s College, University of London, Strand, London, WC2R 2LS, Great Britain

    Peter F. Baker (Professor Sc. D., F.R.S.) (Professor Sc. D., F.R.S.)

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Godfraind, T. (1988). Pharmacology of Calcium Metabolism in Smooth Muscle. In: Baker, P.F. (eds) Calcium in Drug Actions. Handbook of Experimental Pharmacology, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71806-9_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71806-9_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71808-3

  • Online ISBN: 978-3-642-71806-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation