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Exo-Endocytosis: Mechanisms of Drug and Toxin Action

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Book cover Calcium in Drug Actions

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 83))

Abstract

All eukaryotic cells (except red blood cells) share the ability to segregate intracellularly (within membrane-bounded organelles) their specific hydrophilic secretion products (e.g., proteins, peptides, classical neurotransmitters, such as amines, acetylcholine, and amino acids) and to discharge these products by a process known as exocytosis. The term exocytosis was originally proposed to describe the release in bulk of the contents of a membrane-bounded release organelle (named, depending on its size, a granule or a vesicle). The sequence of events leading to the release process includes the fusion of the organelle membrane with the plasmalemma, followed by the fission of the fused membranes. Such a fission, which proceeds by the sequential elimination of membrane layers, creates continuity between the intraorganelle compartment and the extracellular space. With time, the meaning of the term exocytosis has expanded to include not only the release, but also the preceding fusion-fission steps. Such an extended meaning is used throughout this chapter (Palade 1975; Ceccarelli and Hurlbut 1980 a; Meldolesi and Ceccarelli 1981).

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Authors
  1. J. Meldolesi
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  2. T. Pozzan
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  3. B. Ceccarelli
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Editors and Affiliations

  1. Department of Physiology King’s College, University of London, Strand, London, WC2R 2LS, Great Britain

    Peter F. Baker (Professor Sc. D., F.R.S.) (Professor Sc. D., F.R.S.)

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Meldolesi, J., Pozzan, T., Ceccarelli, B. (1988). Exo-Endocytosis: Mechanisms of Drug and Toxin Action. In: Baker, P.F. (eds) Calcium in Drug Actions. Handbook of Experimental Pharmacology, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71806-9_17

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