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Drugs Acting on Calcium Channels

  • Chapter
Calcium in Drug Actions

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 83))

Abstract

Drugs acting on calcium channels have been studied extensively. Calcium antagonists or calcium channel blockers have been the subject of both basic and clinical investigations for some time, and some of them have been developed into useful therapeutic drugs for the treatment of hypertension and coronary disorders (Fleckenstein 1977; Triggle 1981). However, most of these studies were performed with classical pharmacologic techniques involving measurement of muscle contractions and tension. It was not until the early 1980s that the drugs acting on calcium channels became a subject of modern electrophysiologic investigations using voltage-clamp techniques (Hagiwara and Byerly 1981, 1983; Tsien 1983; Pappone and Cahalan 1986; Reuter 1983; Skerritt and Macdonald 1984; Yaksh and Noueihed 1985; Werz and Macdonald 1983 a, 1985; Macdonald and Werz 1986).

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Authors
  1. T. Narahashi
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Editors and Affiliations

  1. Department of Physiology King’s College, University of London, Strand, London, WC2R 2LS, Great Britain

    Peter F. Baker (Professor Sc. D., F.R.S.) (Professor Sc. D., F.R.S.)

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© 1988 Springer-Verlag Berlin Heidelberg

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Narahashi, T. (1988). Drugs Acting on Calcium Channels. In: Baker, P.F. (eds) Calcium in Drug Actions. Handbook of Experimental Pharmacology, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71806-9_14

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  • DOI: https://doi.org/10.1007/978-3-642-71806-9_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71808-3

  • Online ISBN: 978-3-642-71806-9

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