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Phorbol Esters and Protein Kinase C

  • Chapter
Calcium in Drug Actions

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 83))

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Abstract

It is generally accepted that carcinogenesis can be divided into two stages, tumor initiation and promotion. Since these stages can be caused by compounds specific to each, there seem to be two independent processes that are responsible for initiation and promotion. Initial studies of the promotion process utilized croton oil. Today phorbol esters isolated from croton oil as its active components, as well as synthetic analogs with a range of tumor-promoting activity are used for studies of the mechanism of tumor promotion.

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Authors
  1. H. Nagamoto
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  2. U. Kikkawa
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  3. Y. Nishizuka
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Editor information

Editors and Affiliations

  1. Department of Physiology King’s College, University of London, Strand, London, WC2R 2LS, Great Britain

    Peter F. Baker (Professor Sc. D., F.R.S.) (Professor Sc. D., F.R.S.)

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© 1988 Springer-Verlag Berlin Heidelberg

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Nagamoto, H., Kikkawa, U., Nishizuka, Y. (1988). Phorbol Esters and Protein Kinase C. In: Baker, P.F. (eds) Calcium in Drug Actions. Handbook of Experimental Pharmacology, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71806-9_13

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  • DOI: https://doi.org/10.1007/978-3-642-71806-9_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71808-3

  • Online ISBN: 978-3-642-71806-9

  • eBook Packages: Springer Book Archive

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