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Effect of Lithium in Stimulus — Response Coupling

  • Chapter
Calcium in Drug Actions

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 83))

Abstract

Questions on the mode of intracellular action of Li+ have attracted special interest because of its therapeutic effects in manic-depressive illness. The original report of control and prevention of mania by Li+ salts (Cade 1949) initiated widespread use of Li+ for this illness. Since Li+ is most effective in reducing the mood swings of bipolar manic-depressive patients, patients suffering from this disease often take Li+ for the rest of their lives (W. R. Sherman 1986, personal communication). The mode of Li+ action in these patients is not yet clear, although many different functions of Li+ on ion transport systems, enzymes, synaptic transmission, and receptor sensitivity have been described (Emrich et al. 1982) from which a hypothesis has emerged that Li+ modulates central nervous activity by influencing receptor-mediated phosphoinositide metabolism — and consequently also Ca2+ mobilization and control of Ca2+-dependent neurosecretion (Berridge et al. 1982).

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  1. I. Schulz
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  1. Department of Physiology King’s College, University of London, Strand, London, WC2R 2LS, Great Britain

    Peter F. Baker (Professor Sc. D., F.R.S.) (Professor Sc. D., F.R.S.)

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Schulz, I. (1988). Effect of Lithium in Stimulus — Response Coupling. In: Baker, P.F. (eds) Calcium in Drug Actions. Handbook of Experimental Pharmacology, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71806-9_12

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  • DOI: https://doi.org/10.1007/978-3-642-71806-9_12

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