Neuroactive Substances Influencing Regenerative Processes in the Central Nervous System: Neurobiological and Clinical Aspects

  • U. H. Wiese
Conference paper
Part of the Advances in Neurosurgery book series (NEURO, volume 15)


In his influential work published in 1928 under the title “Degeneration and Regeneration of the Nervous System,” RAMÒN Y CAJAL noted: “Once development was ended, the founts of growth and regeneration of the axon dendrites dried up irrevocably. In adult centers, the nerve paths are something fixed, and immutable; everything may die, nothing may be regenerated.” (39) Approximately 50 years later BJÖRKLUND and STENEVI summarized: “It is well established that the adult mammalian brain has the capacity for sprouting, synaptogenesis, and reformation of severed connections (6).” The initial “hard-wired” concept of brain organization did not exclude recovery of function of the central nervous system; early experience of restorative events after brain ischemia resulted in the classical theories of recovery, including the strategy of behavioral compensation, diaschisis (release of uninjured tissue from a temporarily suppressed state), and vicariation (the possibility that one structure can take over another’s function), (for review, see 18). New neuroanatomical and neurophysiological techniques, including anterograde and retrograde tracing of axons and intracellular recordings, resulted in the modern concept of “neuronal plasticity.”


Spinal Cord Sodium Bromide Spinal Cord Blood Flow Spinal Cord Contusion Callosal Projection 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • U. H. Wiese
    • 1
  1. 1.Neurochirurgische AbteilungKrankenhaus mit Rehabilitationsklinik für Rückenmarksverletzte Hohe WarteBayreuthGermany

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