The Effect of Host and Cell Age on the Rat and Human Erythrocyte: Cellular and Immunologic Aspects
The erythrocyte provides a novel model for the study of aging. This cellular system is readily sampled, constantly turning over, and of no synthetic capacity after the reticulocyte stage. As such, the erythrocyte has been studied as a model for cellular aging in young hosts. The erythrocyte provides an equally fascinating model for the study of the effects of host age on cellular aging.
KeywordsHuman Erythrocyte Density Fraction Normal Rabbit Serum Brilliant Cresyl Blue Experimental Hematology
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- Aminoff D (1985) Senescence and sequestration of RBC from circulation. In: Eaton W, Konzen DK, White JG (eds) Cellular and molecular aspects of aging: the red cell as a model. Alan Liss, Inc, New York, pp 279–300Google Scholar
- Bishop C, Prentice TC (1966) Separation of rabbit red cells by density in a bovine serum albumin gradient and correlation of red cell density with cell age after in vivo labeling with Fe59. J Cell Comp Physiol 67:197Google Scholar
- Galili U, Koresh A, Kahane I, Rachmilewitz EA (1984) Demonstration of a natural antigalac-tosyl IgG antibody on thalassemic red blood cells. Blood 61:1258Google Scholar
- Glass GA, Gershon D (1984) Decreased enzymic protection and increased sensitivity to oxidative damage in erythrocytes as a function of cell and donor age. Bioch J 218:531Google Scholar
- Piomelli S, Lurinsky G, Wasserman LJ (1967) The mechanism of red cell aging I. Relationship between cell age and specific gravity evaluated by ultracentrifugation in a discontinuous density gradient. Lab Clin Med 69:659Google Scholar
- Vomel Th, Platt D (1981) Life span of rabbit erythrocytes and activity of the reticulohistiocyte system. Mech Ageing Dev 17:262Google Scholar