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Changes in Human Red Cell Mechanics During In Vivo Aging: Possible Influence on Removal of Senescent Cells

  • Conference paper
Blood Cells, Rheology, and Aging

Abstract

During its life span the human red blood cell undergoes repeated, reversible changes in its shape under the influence of circulatory flow forces. This ability to deform (i.e., cellular deformability) affects the bulk viscosity of the blood and is also a necessary requirement for the cells to pass through narrow vessels with openings smaller than the cell diameter. In these microvessels the concept of a continuum viscosity for blood seems invalid and it is thus necessary to consider the mechanical properties of the individual cells which will influence their passage. Although cellular deformability is rather a vague term, it is generally agreed that it is determined by a group of more specific mechanical properties of the red cell. These mechanical factors can be categorized as either extrinsic properties (cell size and shape) or intrinsic properties (internal viscosity and membrane vis-coelasticity, i.e., structural factors) (Meiselman 1981).

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Authors
  1. G. B. Nash
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  2. O. Linderkamp
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  3. C. Pfafferoth
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  4. H. J. Meiselman
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Editor information

Editors and Affiliations

  1. Instituts für Gerontologie, Universität Erlangen-Nürnberg, Flurstraße 17, D-8500, Nürnberg, Germany

    Dieter Platt (Direktor) (Direktor)

  2. 2. Medizinischen Klinik, Klinikum Nürnberg, Flurstraße 17, D-8500, Nürnberg, Germany

    Dieter Platt (Direktor) (Direktor)

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© 1988 Springer-Verlag Berlin Heidelberg

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Nash, G.B., Linderkamp, O., Pfafferoth, C., Meiselman, H.J. (1988). Changes in Human Red Cell Mechanics During In Vivo Aging: Possible Influence on Removal of Senescent Cells. In: Platt, D. (eds) Blood Cells, Rheology, and Aging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71790-1_10

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  • DOI: https://doi.org/10.1007/978-3-642-71790-1_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71792-5

  • Online ISBN: 978-3-642-71790-1

  • eBook Packages: Springer Book Archive

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