Prognostic Importance of Blood Rheology in Acute Stroke

  • G. D. O. Lowe
  • J. Anderson
  • J. C. Barbenel
  • C. D. Forbes


Increased blood viscosity has been described in patients with acute stroke, associated with elevations of hematocrit and/or plasma fibrinogen concentration [3, 13, 14]. Increased red cell aggregation [8, 11] and decreased blood filterability have also been reported [8, 10, 14, 17]. These rheological abnormalities may promote cerebral ischemia in areas of low blood flow. In patients with cerebral ischemia, hematocrit, fibrinogen, and yield stress showed inverse correlations with cerebral blood flow [6]. Conversely, pilot studies of hemodilution [5, 20] and defibrination [7] have shown encouraging results in treatment of acute cerebral infarction. White cell capillary plugging may also play a role in cerebral ischemia [24], and this may be promoted by the increased white cell count in acute stroke [11].


Cerebral Ischemia Acute Stroke Blood Viscosity Fibrinogen Level White Cell Count 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • G. D. O. Lowe
    • 1
  • J. Anderson
    • 1
  • J. C. Barbenel
    • 2
  • C. D. Forbes
    • 1
  1. 1.University Department of MedicineRoyal InfirmaryGlasgowScotland, UK
  2. 2.Bioengineering UnitUniversity of StrathclydeGlasgowScotland, UK

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