Prognostic Importance of Blood Rheology in Acute Stroke
Increased blood viscosity has been described in patients with acute stroke, associated with elevations of hematocrit and/or plasma fibrinogen concentration [3, 13, 14]. Increased red cell aggregation [8, 11] and decreased blood filterability have also been reported [8, 10, 14, 17]. These rheological abnormalities may promote cerebral ischemia in areas of low blood flow. In patients with cerebral ischemia, hematocrit, fibrinogen, and yield stress showed inverse correlations with cerebral blood flow . Conversely, pilot studies of hemodilution [5, 20] and defibrination  have shown encouraging results in treatment of acute cerebral infarction. White cell capillary plugging may also play a role in cerebral ischemia , and this may be promoted by the increased white cell count in acute stroke .
KeywordsFiltration Ischemia EDTA Citrate Sedimentation
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