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Glycerol and Rheomacrodex in the Treatment of the Acute Ischemic Insult: A Placebo-Controlled Double-Blind Trial

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Cerebral Ischemia and Hemorheology

  • 449 Accesses

Abstract

Stroke is still a major cause of morbidity and death in western societies [9, 30]. Early mortality is reported to be 30% and one out of two survivors suffers permanent disability [23]. The majority of strokes are due to atherothrombotic brain infarction or cerebral embolism [23]. Our understanding of the pathophysiology of acute cerebral ischemia has improved considerably in recent years [8, 29, 34]. Based on this knowledge various therapeutic strategies have been developed. Substances such as glycerol or steroids have been shown to decrease edema formation [1, 4, 5, 22, 25, 27, 38]. Anticoagulants and platelet antiaggregation drugs impede thrombosis [17]. In other experiments the hemorheological effects of dextran have improved regional cerebral blood flow [14, 15, 37]. Drugs that influence cell metabolism, such as prostacyclin or calcium channel blockers [11, 19], have been evaluated.

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Author information

Authors and Affiliations

  1. Kreisspital Rüti, CH-8630, Rüti, Switzerland

    A. Frei

  2. Department of Internal Medicine, University Hospital, CH-4056, Basel, Switzerland

    C. Cottier & P. Wunderlich

Authors
  1. A. Frei
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  2. C. Cottier
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  3. P. Wunderlich
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Editor information

Editors and Affiliations

  1. Neurologische Universitätsklinik, Sigmund-Freud-Str. 25, D-5300, Bonn 1, Germany

    Alexander Hartmann

  2. Physiologisches Institut I, Universität Bonn, Nußallee II, D-5300, Bonn 1, Germany

    Wolfgang Kuschinsky

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© 1987 Springer-Verlag Berlin Heidelberg

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Frei, A., Cottier, C., Wunderlich, P. (1987). Glycerol and Rheomacrodex in the Treatment of the Acute Ischemic Insult: A Placebo-Controlled Double-Blind Trial. In: Hartmann, A., Kuschinsky, W. (eds) Cerebral Ischemia and Hemorheology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71787-1_52

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  • DOI: https://doi.org/10.1007/978-3-642-71787-1_52

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71789-5

  • Online ISBN: 978-3-642-71787-1

  • eBook Packages: Springer Book Archive

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