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Glycerol and Rheomacrodex in the Treatment of the Acute Ischemic Insult: A Placebo-Controlled Double-Blind Trial

  • A. Frei
  • C. Cottier
  • P. Wunderlich
Conference paper

Abstract

Stroke is still a major cause of morbidity and death in western societies [9, 30]. Early mortality is reported to be 30% and one out of two survivors suffers permanent disability [23]. The majority of strokes are due to atherothrombotic brain infarction or cerebral embolism [23]. Our understanding of the pathophysiology of acute cerebral ischemia has improved considerably in recent years [8, 29, 34]. Based on this knowledge various therapeutic strategies have been developed. Substances such as glycerol or steroids have been shown to decrease edema formation [1, 4, 5, 22, 25, 27, 38]. Anticoagulants and platelet antiaggregation drugs impede thrombosis [17]. In other experiments the hemorheological effects of dextran have improved regional cerebral blood flow [14, 15, 37]. Drugs that influence cell metabolism, such as prostacyclin or calcium channel blockers [11, 19], have been evaluated.

Keywords

Acute Stroke Atrial Flutter Regional Cerebral Blood Flow Neurological Score Acute Cerebral Infarction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • A. Frei
    • 1
  • C. Cottier
    • 2
  • P. Wunderlich
    • 2
  1. 1.Kreisspital RütiRütiSwitzerland
  2. 2.Department of Internal MedicineUniversity HospitalBaselSwitzerland

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