Hemodilution in Cerebral Infarction

  • U. Gottstein
Conference paper


Although experimental research on the cerebral circulation has now been intensively concerned for more than three decades with the pathogenesis of cerebral blood flow disorders and with cerebral infarction and its therapy, treatment of cerebral infarction continues to be one of the major problems of medicine. Vasodilatory substances, measures to raise blood pressure, hyperventilation, hyperbaric oxygen therapy, and finally thrombocyte aggregation inhibitors and calcium antagonists have all proved ineffective. There is the continuing great hope that patients with acute cerebral infarction can be effectively helped by means of correctly applied hemodilution therapy. Although this chapter has not yet been finally concluded, numerous research groups have now demonstrated the efficiency of hemodilution in the cerebral circulation, i.e., a marked enhancement of cerebral blood flow in areas of normal and disturbed circulation [see 5].


Cerebral Blood Flow Cerebral Infarction Acute Ischemic Stroke Acute Cerebral Infarction Arterial Oxygen Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Andersen A, Vorstrup S, Juhler M, Brun B, Boysen G (1985) Cerebral blood flow changes during isovolemic hemodilution in acute stroke. Abstracts Satellite Meeting XIII World Congress of Neurology, SienaGoogle Scholar
  2. 2.
    Asplund K (1986) Hemodilution in acute ischemic stroke - a randomized multicenter trial. Stroke 17: 143Google Scholar
  3. 3.
    Brown MM, Wade JPH, Marshall J (1985) Fundamental importance of arterial oxygen content in the regulation of cerebral blood flow in man. Brain 108: 81–93PubMedCrossRefGoogle Scholar
  4. 4.
    Gottstein U (1965) Physiologie und Pathophysiologie des Himkreislaufs. Med Welt 15: 715–726PubMedGoogle Scholar
  5. 5.
    Gottstein U (1984) Hemodilution-therapy in acute ischemic stroke. In: Bes A, Braquet P, Paoletti R, Siesjö BK (eds) Cerebral ischemia. Elsevier Science Publ, Amsterdam, pp 311–324Google Scholar
  6. 6.
    Gottstein U, Held K (1969) The effect of hemodilution caused by low molecular weight dextran on human cerebral blood flow and metabolism. In: Brock M, Fieschi C, Ingvar DH, Lassen NA, Schürmann K (eds) Cerebral blood flow. Springer, Berlin Heidelberg New York, pp 104–105Google Scholar
  7. 7.
    Gottstein U, Held K (1969) Effekt der Hämodilution nach intravenöser Infusion von niedermolekularen Dextranen auf die Himzirkulation des Menschen. Dtsch Med Wochenschr 94: 522–526PubMedCrossRefGoogle Scholar
  8. 8.
    Hartmann A (1985) Regional cerebral blood flow in acute cerebral infarction during hypervolemic hemodilution. In: Meyer JS, Lechner H, Reivich M, Ott EO (eds) Cerebral vascular disease 5. Excerpta Medica, Amsterdam New York Oxford pp 206–214Google Scholar
  9. 9.
    Muizelaar JP, Wei EP, Kontos HA, Becker DP (1986) Cerebral blood flow is regulated by changes in blood pressure and blood viscosity alike. Stroke 17: 44–48PubMedCrossRefGoogle Scholar
  10. 10.
    Strand T, Asplund K, Eriksson ST, Hägg E, Lithner F, Wester PO (1984) A randomized controlled trial of hemodilution therapy in acute ischemic stroke. Stroke 15: 980–989PubMedCrossRefGoogle Scholar
  11. 11.
    Wood JH, Polyzoidis KS, Epstein CM, Gibby GL, Tindall GT (1983) Improvement in cerebral blood flow and power spectral EEG after isovolemic hemodilution in stroke patients. J Cerebral Blood Flow and Metabol 3: 588–589Google Scholar
  12. 12.
    York EL, Jones RL, Menon D, Sproule BJ (1980) Effects of secondary polycythemia on cerebral blood flow in chronic obstructive pulmonary disease. Amer Rev Respir Dis 121: 813–818Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • U. Gottstein
    • 1
  1. 1.Medizinische KlinikBürgerhospitalFrankfurtGermany

Personalised recommendations