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Blood Viscosity and Cerebral Blood Flow

  • Conference paper
Cerebral Ischemia and Hemorheology

Abstract

The blood flow to the brain is largely controlled by the metabolic demand. This determines the rate of delivery of oxygen and the removal of carbon dioxide. Under normal physiological conditions, there is usually considerably circulatory reserve. In patients with occlusive vascular disease, when conditions are becoming critical, the first response is to improve cerebral blood flow by vasodilatation, then if necessary, when conditions become more extreme, by increased oxygen extraction [1].

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References

  1. Gibbs J, Wise RSJ, Leenders KL, Jones T (1984) Evaluation of cerebral perfusion reserve in patients with carotid artery occlusion. Lancet i: 310–314

    Article  Google Scholar 

  2. Scheinberg P (1951) Cerebral blood flow and metabolism in pernicious anaemia. Blood 6: 213–227

    PubMed  CAS  Google Scholar 

  3. Humphrey PRO (1981) Clinical relevance of measurements of cerebral blood flow. Brit Journ Hosp Med 233–241

    Google Scholar 

  4. Thomas DJ, du Boulay GH, Marshall J, Pearson TC, Ross Russell RW, Symon L, Wetherley-Mein G, Zilkha E (1977) Cerebral blood flow in polycythaemia. Lancet ii: 161–162

    Article  Google Scholar 

  5. Elwood PC, Waters WE, Benjamin IT, Sweetman PM (1974) Mortality and anaemia in women. Lancet i: 891–894

    Article  Google Scholar 

  6. Chievitz E, Thiede T (1962) Complications and causes of death in polycythaemia vera. Acta Medica Scandinav 172: 513–523

    Article  CAS  Google Scholar 

  7. Thomas DJ, du Boulay GH, Marshall J, Pearson TC, Ross Russell RW, Symon L, Wetherley-Mein G, Zilkha E (1977) Effect of haematocrit on cerebral blood flow in man. Lancet ii: 941–943

    Article  Google Scholar 

  8. Grotta J, Ackerman R, Correia J, Fallick G, Chang J (1982) Whole blood viscosity parameters in cerebral blood flow. Stroke 13: 296–301

    Article  PubMed  CAS  Google Scholar 

  9. Wade JPH, du Boulay GH, Marshall J, Pearson TC, Ross Russell RW, Shirley JA, Symons L, Wetherley-Mein G, Zilkha E (1980) Cerebral blood flow, haematocrit and viscosity in subjects with high oxygen affinity haemoglobin variant. Acta Neural Scandinav 61: 210–215

    Article  CAS  Google Scholar 

  10. Wade JPH, Pearson TC, Ross Russell RW, Wetherley-Mein G (1981) Cerebral blood flow and blood viscosity in patients with polycythaemia secondary to hypoxic lung disease. BMJ 283: 189–192

    Google Scholar 

  11. Paulson OB, Parving HH, Olesen J, Skinhoj E (1973) Influence of carbon monoxide and of hemodilution on cerebral blood flow and blood gases in man. Journal of Applied Physiology 35: 111–116

    PubMed  CAS  Google Scholar 

  12. Thomas DJ, du Boulay GH, Marshall J, Pearson TC, Ross Russell RW, Symon L, Wetherley-Mein G, Willison JR, Zilkha E (1978) Prevention of stroke — the viscosity factor. In: Meyer JS, Lechner H, Reivich M (eds) Cerebral vascular disease 2, 9th Salzburg Conference, pp 211

    Google Scholar 

  13. Perutz MF, Poyart C (1983) Bezafibrate lowers oxygen affinity of haemoglobin. Lancet ii: 881–882

    Article  Google Scholar 

  14. Humphrey PRD, du Boulay GH, Marshall J, Pearson TC, Ross Russell RW, Slater NGP, Symon L, Wetherley-Mein G, Zilkha E (1980) Viscosity, cerebral blood flow and haematocrit in patients with paraproteinaemia. Acta N eurol Scandinav 61: 201–209

    Article  CAS  Google Scholar 

  15. Brown MM, Marshall J (1982) Effect of plasma exchange on blood viscosity and cerebral blood flow. BMJ 284: 1733–1736

    Article  PubMed  CAS  Google Scholar 

  16. Willison JR, Thomas DJ, du Boulay GH, Marshall J, Paul EA, Pearson TC, Ross Russell RW, Symon L, Wetherley-Mein G (1980) Effect of high haematocrit on alertness. Lancet i: 846–848

    Article  Google Scholar 

  17. Henriksen L, Paulson OB, Smith RJ (1981) Cerebral blood flow following normovolemic hemodilution in patients with high hematocrit. Annals of Neurology 9: 454–457

    Article  PubMed  CAS  Google Scholar 

  18. Wade JPH (1983) Transport of oxygen to the brain in patients with elevated haematocrit values before and after venesection. Brain 106: 513–523

    Article  PubMed  Google Scholar 

  19. Wade JPH (1981) Reactivity of the cerebrovascular bed to carbon dioxide in patients with primary high haematocrit before and after venesection. Acta Neurol Scandinav 63: 306–314

    Article  CAS  Google Scholar 

  20. Pollock S, Tsitsopoulos P, Harrison MJG (1982) The effect ofhaematocrit on cerebral perfusion and clinical status following carotid occlusion in the gerbil. Stroke 13: 167–171

    Article  PubMed  CAS  Google Scholar 

  21. Harrison MJG, Kendall BE, Pollock S, Marshall J (1981) Effect of haematocrit on carotid stenosis and cerebral infarction. Lancet 114–115

    Google Scholar 

  22. Harrison MJG, Mitchell JRA (1966) The influence of red blood cells on platelet adhesiveness. Lancet ii: 1163–1164

    Article  Google Scholar 

  23. Wood JH, Kee DB (1986) Clinical rheology of stroke and haemodilution. In: Barnett HJM, Mohr JP, Stein BM, Yatsu FM (eds) Stroke: pathophysiology, diagnosis and management. Churchill-Livingstone, New York, pp 97–108

    Google Scholar 

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Author information

Authors and Affiliations

  1. St. Mary’s Hospital, W2, London, UK

    D. J. Thomas

  2. Institute of Neurology, Queen Square, WC1, London, UK

    D. J. Thomas

Authors
  1. D. J. Thomas
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Editor information

Editors and Affiliations

  1. Neurologische Universitätsklinik, Sigmund-Freud-Str. 25, D-5300, Bonn 1, Germany

    Alexander Hartmann

  2. Physiologisches Institut I, Universität Bonn, Nußallee II, D-5300, Bonn 1, Germany

    Wolfgang Kuschinsky

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© 1987 Springer-Verlag Berlin Heidelberg

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Thomas, D.J. (1987). Blood Viscosity and Cerebral Blood Flow. In: Hartmann, A., Kuschinsky, W. (eds) Cerebral Ischemia and Hemorheology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71787-1_33

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  • DOI: https://doi.org/10.1007/978-3-642-71787-1_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71789-5

  • Online ISBN: 978-3-642-71787-1

  • eBook Packages: Springer Book Archive

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