The Effect of Brain Edema on the Microcirculation

  • M. D. O’Brien
Conference paper


Although a great deal of effort has been expended on the measurement of cerebral blood flow, it is not an active process in its own right, but only the passive movement of blood in tubes down hydrostatic pressure gradients. Similarly, the movement of water in the brain between various compartments is purely passive, following both hydrostatic and osmotic pressure gradients. The amount of water and the rate at which it moves down these gradients depend on the size of the gradient and on the physical characteristics of the tissues and their membranes, i.e., tissue compliance and membrane permeability [1].


Cerebral Blood Flow Middle Cerebral Artery Brain Edema Cerebral Edema Focal Cerebral Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    O’Brien MD (1979) Ischemic cerebral edema - a review. Stroke 10: 623–628PubMedCrossRefGoogle Scholar
  2. 2.
    Astrup J, Siesjo BK, Symon L (1981) Thresholds in cerebral ischemia — the ischemic penumbra, 12: 723–725Google Scholar
  3. 3.
    Rossmann KA (1976) Development and resolution of ischemic brain swelling. In: Pappius HM, Feindel W (eds) Dynamics of brain edema. New York: Springer-Verlag 219–227CrossRefGoogle Scholar
  4. 4.
    Symon L, Branston NM, Chikovani O (1979) Ischemic brain edema following middle cerebral artery occlusion in baboons. Stroke 10: 184–191PubMedCrossRefGoogle Scholar
  5. 5.
    O’Brien MD, Waltz AG, Jordan MM (1974) Ischemic cerebral edema; distribution of water in the brains of cats after occlusion of the middle cerebral artery. Arch Neurol 30: 456–460PubMedGoogle Scholar
  6. 6.
    Gotoh O, Asano T, Koidae T, Takakura K (1985) Ischemic brain edema following occlusion of the middle cerebral artery in the rat. Stroke 16: 101–109PubMedCrossRefGoogle Scholar
  7. 7.
    Iannotti F, Hoff J, Schielke G (1985) Brain tissue pressure and focal cerebral ischemia. J Neurosurg 62: 83–89PubMedCrossRefGoogle Scholar
  8. 8.
    Little JR (1976) Microvascular alterations and edema in focal cerebral ischemia. In: Pappius HM, Feindel W (eds) Dynamics of brain edema. New York: Springer-Verlag 236–243CrossRefGoogle Scholar
  9. 9.
    Ito U, Ohno K, Nakamura R, Suganuma F, Inaba Y (1979) Brain edema during ischemia and after restoration of blood flow. Stroke 10: 542–547PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • M. D. O’Brien
    • 1
  1. 1.Department of NeurologyGuy’s HospitalLondonUK

Personalised recommendations