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Reducing Cellular Energy Requirements as Protection Against CNS Ischemia

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Cerebral Ischemia and Hemorheology

Abstract

Three considerations, taken together, make research on the treatment of brain ischemia seem eminently worthwhile: (a) during ischemia, tissue destined for infarction is usually receiving an appreciable fraction of the minimum blood flow required for cell survival [7, 10, 13]; (b) the time to irreversibility is considerably longer than previously thought and may be measured in terms of half hours or hours [6, 8]; (c) restoration of circulation usually can be anticipated within hours or days as a result of clot lysis or collateral enlargement. Aggressive measures to forestall cell death may therefore be justified.

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Author information

Authors and Affiliations

  1. Neurosurgical Service, Massachusetts General Hospital, 02114, Boston, MA, USA

    A. Ames III & E. L. Zager

Authors
  1. A. Ames III
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  2. E. L. Zager
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Editor information

Editors and Affiliations

  1. Neurologische Universitätsklinik, Sigmund-Freud-Str. 25, D-5300, Bonn 1, Germany

    Alexander Hartmann

  2. Physiologisches Institut I, Universität Bonn, Nußallee II, D-5300, Bonn 1, Germany

    Wolfgang Kuschinsky

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© 1987 Springer-Verlag Berlin Heidelberg

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Ames, A., Zager, E.L. (1987). Reducing Cellular Energy Requirements as Protection Against CNS Ischemia. In: Hartmann, A., Kuschinsky, W. (eds) Cerebral Ischemia and Hemorheology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71787-1_25

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  • DOI: https://doi.org/10.1007/978-3-642-71787-1_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71789-5

  • Online ISBN: 978-3-642-71787-1

  • eBook Packages: Springer Book Archive

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