Neurogenic Control of Cerebral Circulation

  • L. Edvinsson


A number of basic mechanisms are considered to regulate the cerebral circulation. Firstly, the blood flow to the brain is adjusted to meet the local demand of energy generation by the local release of products of cerebral tissue metabolism. Products of cerebral metabolism are thought to link the flow—metabolism changes. Secondly, chemical factors in the blood, such as carbon dioxide, may induce pronounced changes in cerebral blood flow. Thirdly, the cerebral circulation has an intrinsic system called “autoregulation” whereby resistance in the cerebral circulation is changed to meet systemic pressure changes, all resulting in the constancy of cerebral blood flow. In addition to the above-described mechanisms, the demonstration that brain vessels are innervated by a variety of aminergic and peptidergic nerve fibers has resulted in speculation that there is a neurogenic influence on the brain circulation. The perivascular nerve supply to the cerebral blood vessels may be divided into sympathetic, parasympathetic, and sensory components, as based on recent immunocytochemical studies, showing a diversity of neurotransmitter candidates, some of which coexist and may cooperate.


Cerebral Blood Flow Vasoactive Intestinal Peptide Trigeminal Ganglion Vasoactive Intestinal Polypeptide Cerebral Circulation 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • L. Edvinsson
    • 1
  1. 1.Department of Internal MedicineUniversity HospitalLundSweden

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