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Local Control of the Cerebral Circulation

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Cerebral Ischemia and Hemorheology

Abstract

The close interdependence of functional activity, metabolism, and blood flow in the brain was postulated a century ago by Roy and Sherrington [46]. These authors stated that “the chemical products of cerebral metabolism … can cause variations of the calibre of the cerebral vessels” and concluded that “the brain possesses an intrinsic mechanism by which its vascular supply can be varied locally in correspondence with local variations of functional activity.” The present article shows that this working hypothesis has been verified by a number of experiments but cannot explain all aspects of the close adjustment of cerebral blood flow to the local functional and metabolic demands. Several mechanisms exist in addition to the metabolic control system proposed by Roy and Sherrington [46]; they have become visible after the development of techniques which allow the local measurement of blood flow, metabolism, ionic activities, tissue metabolites, vascular reactions, and capillary density in the brain.

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Author information

Authors and Affiliations

  1. Physiologisches Institut I der Universität Bonn, D-5300, Nussallee 11, Bonn 1, Germany

    W. Kuschinsky

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  1. W. Kuschinsky
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Editors and Affiliations

  1. Neurologische Universitätsklinik, Sigmund-Freud-Str. 25, D-5300, Bonn 1, Germany

    Alexander Hartmann

  2. Physiologisches Institut I, Universität Bonn, Nußallee II, D-5300, Bonn 1, Germany

    Wolfgang Kuschinsky

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© 1987 Springer-Verlag Berlin Heidelberg

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Kuschinsky, W. (1987). Local Control of the Cerebral Circulation. In: Hartmann, A., Kuschinsky, W. (eds) Cerebral Ischemia and Hemorheology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71787-1_1

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  • DOI: https://doi.org/10.1007/978-3-642-71787-1_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71789-5

  • Online ISBN: 978-3-642-71787-1

  • eBook Packages: Springer Book Archive

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