Blood Flow and Glucose Consumption in the Optic Nerve; Effects of High Intraocular Pressure
The anatomy of the optic nerve in man is such as to suggest that there may be great differences in blood flow and metabolic requirements between different parts. In the prelaminar and laminar regions there is practically no myelin while behind the lamina cribrosa the axons become myelinated within the first mm. Myelinated nervous tissue can be expected to have blood flow and metabolic requirements that are lower than those of unmyelinated tissue — myelin requiring next to no nutrition. The optic nerve in monkeys is very similar to that in man and in monkeys determinations of the blood flow in the different regions of the nerve by the microsphere method indicated that there are indeed differences in flow (Ahn and Bill 1973; Geijer and Bill 1979). A recent determination of both blood flow and glucose consumption in different regions of the optic nerve gave results indicating that variations in blood flow are correlated with variations in the metabolic activity (Sperber and Bill 1985). These studies in which one eye had its spontaneous intraocular pressure and the other eye a higher pressure will be reviewed in the following which also contains some unpublished material.
KeywordsIschemia Retina Glaucoma Pentobarbital Cose
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