Distribution of Axonal Transport Injury in the Lamina in Experimental Glaucoma in the Monkey
A modified Pearson’s silver nitrate stain was used to study axonal transport block in the lamina cribrosa of the monkey eye after four hours of acute ocular hypertension. The method used permitted analysis of the distribution of transport block within individual axonal bundles. Experiments were designed to study the earliest detectable injury. Results indicated that transport block occurred first in the posterior lamina along the edges of axonal canals and expanded throughout the bundles as pressure increased. Collagenous and glial beams bounding axonal bundles appeared to indent adjacent axonal bundles, producing a mechanical block of transport.
Key WordsAxonal transport Lamina cribrosa Glaucoma Monkey
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