Pharmacologic Alteration of Aqueous Humor Dynamics in Normotensive and Glaucomatous Monkey Eyes
The results of pharmacologic testing in clinical trials, with drugs that successfully lower intraocular pressure (IOP) in experimental animals, have often been disappointing. The variability in response to drugs amongst the species may be due to differences in anatomy ; drug penetration; and/or receptor quantity, quality, location, or regulation . A reliable and readily available model that closely mimics human glaucoma is needed to determine the efficacy and mechanism of action of potential ocular hypotensive agents prior to embarking upon clinical trials. The normal monkey eye is similar to the human eye with respect to iridocorneal angle anatomy, physiology, and response to ocular hypotensive drugs. The argon laser-induced glaucomatous monkey eye may be a satisfactory model to evaluate the potential efficacy of experimental drugs.
KeywordsVanadate Prostaglandin Epinephrine Indomethacin Prolactin
Unable to display preview. Download preview PDF.
- Camras CB, Podos SM, Rosenthal JS, Lee P-Y, Severin CH (1987) Multiple dosing of Prostaglandin F2α or epinephrine on cynomolgus monkey eyes: I. Aqueous humor dynamics. iInvest Ophthalmol Vis Sci (in press)Google Scholar
- Serie JB, Stein AJ, Podos SM, Severin CH (1984) Corynanthine and aqueous humor dynamics in rabbits and monkeys. Arch Ophthalmol 102:1385–1388Google Scholar
- Siegel MJ, Lee P-Y, Podos SM, Mittag T, Wayne R (1986) Effects of topical pergolide on aqueous dynamics in normal and glaucomatous monkeys. Invest Ophthalmol Vis Sci [Suppl] (in press)Google Scholar
- Crawford K, True B, Kaufman PL (1985) Topical Prostaglandin effects on aqueous humor dynamics in cynomolgus monkeys. Invest Ophthalmol Vis Sci [Suppl] 26:233Google Scholar
- Lee P-Y, Podos SM, Serie JB, Camras CB, Severin CH (1987) Pharmacological testing of multiple dose drugs in the laser-induced monkey glaucoma model. Arch Ophthalmol (in press)Google Scholar
- Serie JB, Podos SM, Lustgarten JS, Teitelbaum C, Severin CH (1985) The effect of corynanthine on intraocular pressure in clinical trials. Ophthalmology 92:977–980Google Scholar
- Brogliatti B, Rolle T, Messelod M, Carenini BB (1985) A new alpha-blocking agent in the treatment of glaucoma: dapiprazole. Glaucoma 7:232–236Google Scholar
- Krupin T, Podos SM, Becker B (1983) Ocular effects of vanadate. Krieglstein GK, Leydhecker W (eds) Glaucoma update IL Springer, Berlin Heidelberg New York Tokyo, pp 25–28Google Scholar
- Badian M, Dabrowski J, Grigoleit HG, Lieb W, Linder E, Rupp W (1984) Effect of forskolineyedrops on the intraocular pressure of healthy male subjects. Klin Mbl Augenheilk 522-526Google Scholar
- Sears ML (1985) Regulation of aqueous flow by the adenylate cyclase receptor complex in the ciliary epithelium. Amer J Ophthalmol 100:194–198Google Scholar
- Caprioli J, Sears M, Kosley R, Cherill R, Huger F (1985) Cyclase activation and IOP reduction by forskolin analogs. Invest Ophthalmol Vis Sci [Suppl] 26:233Google Scholar
- Horowitz RS, Camras CB, Lee P-Y, Podos SM (1986) Possible role of Prostaglandins in the reduction of intraocular pressure (IOP) after argon laser trabeculoplasty in cats. Invest Ophthalmol Vis Sci [Suppl] 27:165Google Scholar