Pharmacologic Alteration of Aqueous Humor Dynamics in Normotensive and Glaucomatous Monkey Eyes
The results of pharmacologic testing in clinical trials, with drugs that successfully lower intraocular pressure (IOP) in experimental animals, have often been disappointing. The variability in response to drugs amongst the species may be due to differences in anatomy ; drug penetration; and/or receptor quantity, quality, location, or regulation . A reliable and readily available model that closely mimics human glaucoma is needed to determine the efficacy and mechanism of action of potential ocular hypotensive agents prior to embarking upon clinical trials. The normal monkey eye is similar to the human eye with respect to iridocorneal angle anatomy, physiology, and response to ocular hypotensive drugs. The argon laser-induced glaucomatous monkey eye may be a satisfactory model to evaluate the potential efficacy of experimental drugs.
KeywordsAqueous Humor Cynomolgus Monkey Outflow Facility Argon Laser Trabeculoplasty Aqueous Flare
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