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Desensitization of the β-Adrenergic Coupled Adenylate Cyclase. The β-Adrenergic Receptor Kinase Phosphorylates Agonist-Occupied Cyclase-Coupled Receptors

  • R. H. Strasser
  • J. L. Benovic
  • M. G. Caron
  • R. J. Lefkowitz
Conference paper
Part of the NATO ASI Series book series (volume 6)

Abstract

Many membrane bound hormone receptors are coupled to the adenylate cyclase system, and function as mediators of the hormonal stimulation at the cell surface (27). The activity of the effector enzyme, the adenylate cyclase is dually regulated via stimulatory and inhibitory receptors (27,15). After activation by a hormone stimulatory receptors like the β-adrenergic receptors and the prostaglandin E1 receptors couple to the stimulatory guanine nucleotide regulatory protein (Ns-protein) to stimulate the adenylate cyclase, while inhibitory receptors like the α2-adrenergic receptors couple to the inhibitory guanine nucleotide regulatory protein or N1-protein to inhibit the adenylate cyclase (15). Yet prolonged exposure to a hormone — stimulatory or inhibitory — leads to a decreased response to further activation of that receptor, a general phenomenon called tachyphylaxis or desensitization. One of the best studied models for desensitization is the β-adrenergic coupled adenylate cyclase (18, 24, 26).

Keywords

Adenylate Cyclase Receptor Kinase Adrenergic Receptor Intracellular cAMP Level Plasma Membrane Fraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • R. H. Strasser
    • 1
  • J. L. Benovic
    • 1
  • M. G. Caron
    • 1
  • R. J. Lefkowitz
    • 1
  1. 1.Duke University Medical CenterDurhamUSA

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