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Glucagon Desensitization of Adenylate Cyclase in Hepatocytes: An Action Mediated by a Distinct Population of Glucagon Receptors Coupled to Stimulate Inositol Phospholipid Metabolism

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Molecular Mechanisms of Desensitization to Signal Molecules

Part of the book series: NATO ASI Series ((ASIH,volume 6))

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Abstract

Many tissues when challenged with hormones able to stimulate adenylate cyclase exhibit a rapid but brief rise in the intracellular concentrations of cyclic AMP. The transience of this response, which may endure for merely minutes, is due to desensitization.

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Author information

Authors and Affiliations

  1. Molecular Pharmacology Group, Department of Biochemistry, University of Glasgow, G12 8QQ, Glasgow, Scotland, UK

    Miles D. Houslay, Gregory J. Murphy, Clare M. Heyworth, Nigel J. Pyne & Michael J. O. Wakelam

Authors
  1. Miles D. Houslay
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  2. Gregory J. Murphy
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  3. Clare M. Heyworth
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  4. Nigel J. Pyne
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  5. Michael J. O. Wakelam
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Editor information

Editors and Affiliations

  1. Zoölogisch Laboratorium, Kaiserstraat 63, Postbus 9516, 2300 RA, Leiden, The Netherlands

    T. M. Konijn  & P. J. M. Van Haastert  & 

  2. Van Beethovenlaan 5, 3161 RV, Rhoon, The Netherlands

    H. Van der Wel

  3. Molecular Pharmacology Group, Department of Biochemistry, University of Glasgow, G12 8QQ, Glasgow, Scotland

    M. D. Houslay

  4. Kennistransfer, University of Leiden, Stationsweg 46, Postbus 9500, 2300 RA, Leiden, The Netherlands

    H. Van der Starre

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© 1987 Springer-Verlag Berlin Heidelberg

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Houslay, M.D., Murphy, G.J., Heyworth, C.M., Pyne, N.J., Wakelam, M.J.O. (1987). Glucagon Desensitization of Adenylate Cyclase in Hepatocytes: An Action Mediated by a Distinct Population of Glucagon Receptors Coupled to Stimulate Inositol Phospholipid Metabolism. In: Konijn, T.M., Van der Wel, H., Van Haastert, P.J.M., Houslay, M.D., Van der Starre, H. (eds) Molecular Mechanisms of Desensitization to Signal Molecules. NATO ASI Series, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71782-6_5

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  • DOI: https://doi.org/10.1007/978-3-642-71782-6_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71784-0

  • Online ISBN: 978-3-642-71782-6

  • eBook Packages: Springer Book Archive

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