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Adaptation, Periodic Signaling, and Receptor Modification

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Molecular Mechanisms of Desensitization to Signal Molecules

Part of the book series: NATO ASI Series ((ASIH,volume 6))

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Abstract

Sensory and other signal transduction systems have evolved the property of adaptation to constant stimuli. Prolonged stimulation of such systems elicits a biphasic physiological response: after passing through a maximum, the response attenuates and sometimes returns precisely to the prestimulus level, despite the increase in stimulus. This phenomenon of exact adaptation occurs in sensory systems such as bacterial Chemotaxis (1) and cAMP secretion in the slime mold Dictyostelium discoideum (2).

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Author information

Authors and Affiliations

  1. Faculté des Sciences, Université Libre de Bruxelles, Campus Plaine, C.P. 231, B-1050, Brussels, Belgium

    Albert Goldbeter

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  1. Albert Goldbeter
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Editor information

Editors and Affiliations

  1. Zoölogisch Laboratorium, Kaiserstraat 63, Postbus 9516, 2300 RA, Leiden, The Netherlands

    T. M. Konijn  & P. J. M. Van Haastert  & 

  2. Van Beethovenlaan 5, 3161 RV, Rhoon, The Netherlands

    H. Van der Wel

  3. Molecular Pharmacology Group, Department of Biochemistry, University of Glasgow, G12 8QQ, Glasgow, Scotland

    M. D. Houslay

  4. Kennistransfer, University of Leiden, Stationsweg 46, Postbus 9500, 2300 RA, Leiden, The Netherlands

    H. Van der Starre

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© 1987 Springer-Verlag Berlin Heidelberg

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Goldbeter, A. (1987). Adaptation, Periodic Signaling, and Receptor Modification. In: Konijn, T.M., Van der Wel, H., Van Haastert, P.J.M., Houslay, M.D., Van der Starre, H. (eds) Molecular Mechanisms of Desensitization to Signal Molecules. NATO ASI Series, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71782-6_4

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  • DOI: https://doi.org/10.1007/978-3-642-71782-6_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71784-0

  • Online ISBN: 978-3-642-71782-6

  • eBook Packages: Springer Book Archive

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