Antibody Induced Down Regulation of Membrane Receptors in Human Diseases

  • F. Clementi
  • E. Sher
Conference paper
Part of the NATO ASI Series book series (volume 6)


During this meeting we have learned of several mechanisms that the cells put forward to cope with a large number of messages that reach their plasmamembrane. The most relevant is the desensitization of neurotransmitter receptors obtained by at least two mechanisms:
  1. 1)

    a change in the protein structure of the receptor by covalent modifications (methylation and phosphorylation, being the most important) resulting in an uncoupling of the receptors from the effector molecules or in a modification of ion channels characteristics.

  2. 2)

    a removal of the receptors from the cell membrane by internalization or by sequestration in the membrane itself.



Insulin Receptor Neuromuscular Junction Nicotinic Receptor Receptor Internalization Acanthosis Nigricans 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • F. Clementi
    • 1
  • E. Sher
    • 1
  1. 1.CNR Center of Cytopharmacology, Dept. of PharmacologyUniversity of MilanMilanoItaly

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