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Cell Responses to Phosphoinositide-Hydrolysing Receptors: Some Potential Sites of Modulation

  • Conference paper
Molecular Mechanisms of Desensitization to Signal Molecules

Part of the book series: NATO ASI Series ((ASIH,volume 6))

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Abstract

Many receptors, originally grouped together as Ca2+-mobilising receptors, are now known to share an ability to couple to phospholipase C and to thereby stimulate hydrolysis of a specific class of phospholipids, the phosphoinositides. An important consequence of activation of phospholipase C is that two intracellular products are generated. One of these, inositol 1,4,5-trisphosphate ((1,4,5)IP3, is water-soluble and enters the cytosol; the second product, 1,2 diacylglycerol (DG), remains in the plasma membrane. In addition to their roles as intracellular signal molecules, both (1,4,5)IP3 and DG are substrates for further metabolic pathways that may either inactivate their signalling properties or perhaps generate further intracellular messengers. Clearly, by comparison with receptors that regulate adenylate cyclase activity or the permeability of ion channels, the phosphoinositide-hydrolysing receptors control a more complex signalling pathway.

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Author information

Authors and Affiliations

  1. Department of Zoology, Downing Street, Cambridge, CB2 3EJ, UK

    Colin W. Taylor

Authors
  1. Colin W. Taylor
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Editor information

Editors and Affiliations

  1. Zoölogisch Laboratorium, Kaiserstraat 63, Postbus 9516, 2300 RA, Leiden, The Netherlands

    T. M. Konijn  & P. J. M. Van Haastert  & 

  2. Van Beethovenlaan 5, 3161 RV, Rhoon, The Netherlands

    H. Van der Wel

  3. Molecular Pharmacology Group, Department of Biochemistry, University of Glasgow, G12 8QQ, Glasgow, Scotland

    M. D. Houslay

  4. Kennistransfer, University of Leiden, Stationsweg 46, Postbus 9500, 2300 RA, Leiden, The Netherlands

    H. Van der Starre

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© 1987 Springer-Verlag Berlin Heidelberg

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Taylor, C.W. (1987). Cell Responses to Phosphoinositide-Hydrolysing Receptors: Some Potential Sites of Modulation. In: Konijn, T.M., Van der Wel, H., Van Haastert, P.J.M., Houslay, M.D., Van der Starre, H. (eds) Molecular Mechanisms of Desensitization to Signal Molecules. NATO ASI Series, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71782-6_12

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  • DOI: https://doi.org/10.1007/978-3-642-71782-6_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71784-0

  • Online ISBN: 978-3-642-71782-6

  • eBook Packages: Springer Book Archive

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