Adaptations of Receptor-Dependent Phosphatidylinositol 4,5-Bisphosphate Breakdown
Many ligands which bind to specific cell-surface receptors exert their intracellular effects via common signal-transduction pathways. One such pathway, used by a wide variety of hormones and neurotransmitters, involves perturbation of the metabolism of intracellular, inositol-containing compounds. The precise relationship between changes in inositol metabolism and other cellular responses to receptor activation are not yet fully understood. It is clear however, that two important consequences of receptor activation are an increase in the intracellular, steady-state levels of DG and Insl45P3, which are known to activate protein kinase C and discharge an intracellular Ca2+-pool respectively , , . The activation of protein kinase C and an increase in the concentration of cytosolic free Ca2+ ([Ca2+]i) are, in turn, responsible for mediating a number of responses to external stimulation e.g. smooth muscle contraction or secretion of the contents of intracellular granules.
KeywordsInositol Phosphate Inositol Trisphosphate Inositol Phospholipid Parotid Acinar Cell Monoester Phosphate
inositol 1 4-bisphosphate
phosphatidyl inosi toi
phosphatidylinosi tol 4-phosphate
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