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Adaptations of Receptor-Dependent Phosphatidylinositol 4,5-Bisphosphate Breakdown

  • C. P. Downes
  • J. E. Merritt
  • P. T. Hawkins
Conference paper
Part of the NATO ASI Series book series (volume 6)

Abstract

Many ligands which bind to specific cell-surface receptors exert their intracellular effects via common signal-transduction pathways. One such pathway, used by a wide variety of hormones and neurotransmitters, involves perturbation of the metabolism of intracellular, inositol-containing compounds. The precise relationship between changes in inositol metabolism and other cellular responses to receptor activation are not yet fully understood. It is clear however, that two important consequences of receptor activation are an increase in the intracellular, steady-state levels of DG and Insl45P3, which are known to activate protein kinase C and discharge an intracellular Ca2+-pool respectively [1], [2], [3]. The activation of protein kinase C and an increase in the concentration of cytosolic free Ca2+ ([Ca2+]i) are, in turn, responsible for mediating a number of responses to external stimulation e.g. smooth muscle contraction or secretion of the contents of intracellular granules.

Keywords

Inositol Phosphate Inositol Trisphosphate Inositol Phospholipid Parotid Acinar Cell Monoester Phosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

DG

Diacylglycerol

Insl34P3

inositol 145-trisphosphate

Insl45P3

inositol 134-trisphosphate

Ins1345P4

inositol 1345-tetrakisphosphate

Ins14P2

inositol 1 4-bisphosphate

InsP

inositol monophosphate

PtdIns

phosphatidyl inosi toi

PtdIns4P

phosphatidylinosi tol 4-phosphate

PtdIns45P2

phosphatidylinositol 45-bisphosphate

PIC

phosphoinositidase C

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • C. P. Downes
    • 1
  • J. E. Merritt
    • 1
  • P. T. Hawkins
    • 1
  1. 1.Department of Cellular PharmacologySmith Kline and French Research LimitedHertfordshireUK

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