Skip to main content

Vascular Growth Factors and Atherogenesis in Diabetes Mellitus

  • Chapter

Abstract

Severe and premature atherosclerosis often occurs in type 1 as well as in type 2 diabetic patients. The diabetes-specific reasons for this are still poorly understood [1]. Within the various pathomechanisms that are involved in the development of macrovascular disease, alterations in the growth of arterial wall cells have received increased attention, and abnormally increased growth of vacular cells is well-established as an intrinsic part of atherogenesis [2]. This paper will focus on the potential relevance of vascular growth stimulating factors that could initiate or accelerate growth of human arterial wall cells, in relation to atherogenesis in diabetes mellitus.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Rudermann NB, Haudenschild C (1984) Diabetes as an atherogenic factor. Progr Cardiovasc Dis 26: 373–412

    Article  Google Scholar 

  2. Schwartz SM, Ross R (1984) Cellular proliferation in atherosclerosis and hypertension. Progr Cardiovasc Dis 26: 355–372

    Article  CAS  Google Scholar 

  3. Benditt EP (1977) Implications of the monoclonal character of human atherosclerotic plaques. Am J Pathol 86: 693–702

    PubMed  CAS  Google Scholar 

  4. Denes R, Lehmann R, Nienhaus R (1983) Evidence of the heterogeneity of the proliferative activity in experimental diabetes. Acta Histochem 27 [Suppl]: 259–264

    CAS  Google Scholar 

  5. Hauss WH, Mey J, Schulte H (1979) Effect of risk factors and anti-rheumatic drugs on the proliferation of aortic wall cells. Atherosclerosis 34: 119–143

    Article  PubMed  CAS  Google Scholar 

  6. Bowersox JC, Sorgente N (1985) Altered growth kinetics of dermal fibroblasts and arterial smooth muscle cells from spontaneously diabetic BB rats. Diabetes 34: 628–633

    Article  PubMed  CAS  Google Scholar 

  7. Griinwald J, Hesz A, Robenek H, Briicker J, Buddecke E (1985) Proliferation, morphology, and low-density lipoprotein metabolism of arterial endothelial cells cultured from normal and diabetic minipigs. Exp Mol Pathol 42: 60–70

    Article  Google Scholar 

  8. Dolgov W, Zainkina OE, Bondarenko MF, Repin VS (1982) Aortic endothelium of alloxan diabetic rabbits: a quantitative study using scanning electron microscopy. Diabetologia 22: 338–343

    Article  PubMed  CAS  Google Scholar 

  9. Ledet T, Fischer Dzoga K, Wissler RW (1976) Growth of rabbit aortic smooth-muscle cells cultured in media containing diabetic and hyperlipemic serum. Diabetes 25: 207–215

    Article  PubMed  CAS  Google Scholar 

  10. Koschinsky T, Bunting CE, Schwippert B, Gries FA (1979) Increased growth of human fibroblasts and arterial smooth muscle cells from diabetic patients related to diabetic serum factors and cell origin. Atherosclerosis 33: 245–252

    Article  PubMed  CAS  Google Scholar 

  11. Koh MS, Majewski BBJ, Rhodes EL (1985) Diabetic serum stimulates the proliferation of endothelial cells in culture. Diabetes Res 2: 287–289

    PubMed  CAS  Google Scholar 

  12. Gerich JE (1984) Role of growth hormone in diabetes mellitus. N Engl J Med 310: 848–850

    Article  PubMed  CAS  Google Scholar 

  13. Ledet T (1977) Growth hormone anti-serum suppresses the growth effect of diabetic serum. Diabetes 26: 798–803

    Article  PubMed  CAS  Google Scholar 

  14. Merimee TJ, Zapf J, Froesch ER (1983) Insulin-like growth factors: studies in diabetics with and without retinopathy. N Engl J Med 309: 527–530

    Article  PubMed  CAS  Google Scholar 

  15. Zapf J, Schoenle E, Froesch ER (1978) Insulin-like growth factors I and II: some biological actions and receptor binding characteristics of two purified constituents of non-suppressible insulin-like activity of human serum. Eur J Biochem 87: 285–296

    Article  PubMed  CAS  Google Scholar 

  16. Stiles CD, Capone GT, Sher CD (1979) Dual control of cell growth by somatomedins and platelet-derived growth factor. Proc Natl Acad Sci USA 76: 1279–1283

    Article  PubMed  CAS  Google Scholar 

  17. Rechler MM (1979) Receptors for somatomedins and related peptides. In: Waldhausel WK (ed) Diabetes. Excerpta Medica, Amsterdam, pp 266–271

    Google Scholar 

  18. King GL, Goodman AD, Buzney S, Moses A, Kahn CR (1985) Receptors and growth-promoting effects of insulin and insulin-like growth factors on cells from bovine retinal capillaries and aorta. J Clin Invest 75: 1028–1036

    Article  PubMed  CAS  Google Scholar 

  19. King GL (1985) Cell biology as an approach to the study of the vascular complications of diabetes. Metabolism 34 [Suppl 1]: 17–34

    PubMed  CAS  Google Scholar 

  20. Stout RW (1985) Overview of the association between insulin and atherosclerosis. Metabolism 34 [Suppl 1]: 7–12

    PubMed  CAS  Google Scholar 

  21. Hillson RM, Hockaday TDR, Mann JI, Newton DJ (1984) Hyperinsulinemia is associated with development of electrocardiographic abnormalities in diabetics. Diabetes Res 1: 143–149

    PubMed  CAS  Google Scholar 

  22. Standi E, Janka HU (1985) High serum insulin concentrations in relation to other cardiovascular risk factors in macro vascular disease of type 2 diabetes. Horm Metab Res [Suppl] 15: 46–51

    Google Scholar 

  23. Pfeifle B, Ditschuneit H (1981) Effect of insulin on the growth of cultured human arterial smooth muscle cells. Diabetologia 20: 155–158

    Article  PubMed  CAS  Google Scholar 

  24. Koschinsky T, Bunting CE, Riitter R, Gries FA (1985) Sera from type 2 (non-insulin-dependent) diabetic and healthy subjects contain different amounts of a very low molecular weight growth peptide for vascular cells. Diabetologia 28: 223–228

    Article  PubMed  CAS  Google Scholar 

  25. Taggart H, Stout RW (1980) Control of DNA synthesis in cultured vascular endothelial and smooth muscle cell. Atherosclerosis 37: 549–557

    Article  PubMed  CAS  Google Scholar 

  26. Straus SD (1984) Growth-stimulatory actions of insulin in vitro and in vivo. Endocrinol Rev 5: 356–369

    Article  CAS  Google Scholar 

  27. Ross R, Vogel A (1978) The platelet-derived growth factor. Cell 14: 203–210

    Article  PubMed  CAS  Google Scholar 

  28. Antoniades HN, Scher CD, Stiles CD (1979) Purification of human platelet-derived growth factor. Proc Natl Acad Sci USA 76: 1809–1812

    Article  PubMed  CAS  Google Scholar 

  29. Heldin CH, Westermark B, Wasteson A (1979) Platelet-derived growth factor: purification and partial characterization. Proc Natl Acad Sci USA 76: 3722–3725

    Article  PubMed  CAS  Google Scholar 

  30. Ross R, Bowen-Pope DF, Raines EW(1985) Platelet-derived growth factor: its potential roles in wound healing, atherosclerosis, neoplasia, and growth and development. Ciba Found Symp 116: 98–112

    Google Scholar 

  31. King GL, Buchwald S (1984) Characterization and partial purification of an endothelial cell growth factor from human platelets. J Clin Invest 73: 392–396

    Article  PubMed  CAS  Google Scholar 

  32. Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn DB (1983) Transforming growth factor-ß in human platelets. J Biol Chem 258: 7155–7160

    PubMed  CAS  Google Scholar 

  33. Assoian RK, Grotendorst GR, Miller DM, Sporn MB (1984) Cellular transformation by coordinated action of three peptide growth factors from human platelets. Nature 309: 804–806

    Article  PubMed  CAS  Google Scholar 

  34. Miyazono K, Okabe T, Ishibashi S, Urabe A, Takaku F (1985) A platelet factor stimulating the proliferation of vascular endothelial cells. Exp Cell Res 159: 487–494

    Article  PubMed  CAS  Google Scholar 

  35. Ross R (1986) Growth factors, platelets, macrophages and atherosclerosis. In: Fidge NH, Nestel PJ (eds) Atherosclerosis VII. Elsevier, Amsterdam, pp 355–358 (International congress series 696 )

    Google Scholar 

  36. Baird A, Esch F, Mormede P, Ueno N, Ling N, Böhlen P, Jing S-J, Wehrenberg WB, Guillemin R (1986) Molecular characterization of fibroblast growth factor: distribution and biological activities in various tissues. Hor Res 42: 143–205

    CAS  Google Scholar 

  37. Oka Y, Orth N (1983) Human plasma epidermal growth factor/ß-urogastrone is associated with blood platelets. J Clin Invest 72: 249–259

    Article  PubMed  CAS  Google Scholar 

  38. Clemmons DR, William LI, Brown MT (1983) Dialyzable factor in human serum of platelet origin stimulates endothelial cell replication and growth. Proc Natl Acad Sci USA 80: 1641–1645

    Article  PubMed  CAS  Google Scholar 

  39. Koschinsky T, Bünting CE, Schwippert B, Gries FA (1980) Increased growth stimulation of fibroblasts from diabetics by diabetic serum factors of low molecular weight. Atherosclerosis 37: 311–317

    Article  PubMed  CAS  Google Scholar 

  40. Koschinsky T, Bünting CE, Schwippert B, Gries FA (1981) Regulation of diabetic serum growth factors for human vascular cells by the metabolic control of diabetes mellitus. Atherosclerosis 39: 313–319

    Article  PubMed  CAS  Google Scholar 

  41. Koschinsky T, Bünting CE, Rütter R, Gries FA (1983) Diabetic growth peptides of very low molecular weight for human vascular cells in serum from type 2 (non insulin-dependent) diabetic patients. Diabetologia 25: 172–173

    Google Scholar 

  42. Koschinsky T, Bünting CE, Rütter R, Schütze R, Gries FA (1985) Diabetic serum growth factor: a new low molecular weight growth peptide for arterial smooth muscle cells of platelet origin. Monogr Atheroscler 13: 159–163

    PubMed  CAS  Google Scholar 

  43. Born MN (1978) Platelet function in diabetes mellitus. Diabetes 27: 342–350

    Google Scholar 

  44. Colwell JA, Lopes-Virella M, Halushka PV (1981) Pathogenesis of atherosclerosis in diabetes. Diabetes Care 4: 121–133

    Article  PubMed  CAS  Google Scholar 

  45. Hamet P, Sugimoto H, Umeda F, Lecavalier L, Franks DJ, Orth DN, Chiasson J-L (1985) Abnormalities of platelet-derived growth factors in insulin-dependent diabetes. Metabolism 34 [Suppl 1]: 25–31

    Article  PubMed  CAS  Google Scholar 

  46. Bowen-Pope DF, Ross R, Seifert R (1985) Locally acting growth factors for vascular cells. Circulation 72: 735–740

    Article  PubMed  CAS  Google Scholar 

  47. DiCorleto PE, Gajdusek CM, Schwartz SM, Ross R (1983) Biochemical properties of the endothelium-derived growth factor: comparison to other growth factors. J Cell Physiol 114: 339–345

    Article  PubMed  CAS  Google Scholar 

  48. Gajdusek CM (1984) Release of endothelial cell-derived growth factor (ECDGF) by heparin. J Cell Physiol 121: 13–21

    Article  PubMed  CAS  Google Scholar 

  49. Campbell JH, Campbell GR (1986) Endothelial cell influences on vascular smooth muscle phenotype. Annu Rev Physiol 48: 295–306

    Article  PubMed  CAS  Google Scholar 

  50. Stavenow L, Tejler L (1985) Growth stimulating activity from lysed cultured arterial smooth muscle cells and skin fibroblasts. Med Biol 63: 175–181

    PubMed  CAS  Google Scholar 

  51. Clemmons DR (1985) Variables controlling the secretion of a somatomedin-like peptide by cultured porcine smooth muscle cells. Circ Res 56: 418–426

    PubMed  CAS  Google Scholar 

  52. Clemmons DR, Van Wyk JJ (1985) Evidence for a functional role of endogenously produced somatomedinlike peptides in the regulation of DNA synthesis in cultured human fibroblasts and porcine smooth muscle cells. J Clin Invest 75: 1914–1918

    Article  PubMed  CAS  Google Scholar 

  53. Millis AJT, Hoyle M, Field B (1977) Human fibroblast conditioned media contains growth-promoting activities for low density cells. J Cell Physiol 93: 17–24

    Article  PubMed  CAS  Google Scholar 

  54. Satoh T, Kan M, Kato M, Yamane I (1986) Purification and characterization of an endothelial cell growth factor from serum-free culture medium of human diploid fibroblast cells. Biochim Biophys Acta 887: 86–93

    Article  PubMed  CAS  Google Scholar 

  55. Martin BM, Gimbrone MA, Unanue ER, Cotran RS (1981) Stimulation of nonlymphoid mesenchymal cell proliferation by a macrophage-derived growth factor. J Immunol 126: 1510–1515

    PubMed  CAS  Google Scholar 

  56. Glenn KC, Ross R (1981) Human monocyte-derived growth factor(s) for mesenchymal cells: activation of secretion by endotoxin and concanavalin A. Cell 25: 603–615

    Article  PubMed  CAS  Google Scholar 

  57. Libby P, Wyler DJ, Janicka MW, Dinarello CA (1985) Differential effects of human interleukin–1 on growth of human fibroblasts and vascular smooth muscle cells. Arteriosclerosis 5: 186–191

    Article  PubMed  CAS  Google Scholar 

  58. Martinet Y, Bitterman PB, Mornex JF, Grotendorst GR, Martin GR, Crystal RG (1986) Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity. Nature 319: 158–160

    Article  PubMed  CAS  Google Scholar 

  59. Kitahara M, Eyre HJ, Lynch RE, Rallison ML, Hill HR (1980) Metabolic activity of diabetic monocytes. Diabetes 29: 251–256

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Koschinsky, T., Gries, F.A. (1987). Vascular Growth Factors and Atherogenesis in Diabetes Mellitus. In: Schlierf, G., Mörl, H. (eds) Expanding Horizons in Atherosclerosis Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71753-6_33

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71753-6_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71755-0

  • Online ISBN: 978-3-642-71753-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics