Chylomicron Catabolism and Uptake by the Liver

  • E. Windler
  • H. Greten


Chylomicrons carry lipids of intestinal origin to peripheral tissues and the liver. The lipids are of two sources. First, there are the endogenous lipids of desquamated intestinal epithelial cells and the bile. Secondly, exogenous lipids of dietary origin are absorbed. This latter source is the most important for triglycerides, while much of the cholesterol and phospholipids follow the conservative cycle of endogenous lipids being reabsorbed. As the quantity of triglycerides determines the size of chylomicron particles, postprandially their diameter rises up to 2000 Å or more. That is why chylomicrons are postprandially easily recognized in the blood stream, although they are continuously secreted. The particles produced in the fasting state are much smaller with a diameter in the range of 500 Å, which is similar to that of very low density lipoproteins (VLDL) of hepatic origin. For this reason these “small chylomicrons” are also referred to as “intestinal VLDL”, which gives rise to confusion as the catabolic pathways of chylomicrons and VLDL differ considerably [1].


Lipoprotein Lipase High Density Lipoprotein Hepatic Uptake Chylomicron Remnant Endogenous Lipid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Windler E, Beil U, Greten H (1986) Der Dünndarm als Lipidstoffwechselorgan. In: Caspary WF (ed) Struktur und Funktion des Dünndarms in Diabetes Form I. Excerpta Medica, Amsterdam (to be published)Google Scholar
  2. 2.
    Green PHR, Glickman RM (1981) Intestinal lipoprotein metabolism. J Lipid Res 22: 1153–1173PubMedGoogle Scholar
  3. 3.
    Kane JP, Hardman DA, Paulus HE (1980) Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons. Proc Natl Acad Sei USA 77: 2465–2469CrossRefGoogle Scholar
  4. 4.
    Windler E, Chao Y, Havel RJ (1980) Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. J Biol Chem 255: 8303–8307PubMedGoogle Scholar
  5. 5.
    Windler E, Chao Y, Havel RJ (1980) Determinants of hepatic-uptake of triglyceride-rich lipoproteins and their remnants in the rat. J Biol Chem 255: 5475–5480PubMedGoogle Scholar
  6. 6.
    Windler E, Havel RJ (1985) Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver. J Lipid Res 26: 556–565PubMedGoogle Scholar
  7. 7.
    Schrecker O, Greten H (1979) Activation and inhibition of lipoprotein lipase-studies with artificial lipoproteins. Biochim Biophys Acta 572: 244–256PubMedGoogle Scholar
  8. 8.
    Windler EET, Preyer S, Greten H (1986) Influence of lysophosphatidylcholine and the C-apolipoprotein content of rat and human triglyceride-rich lipoproteins during triglyceride hydrolysis. J Clin Invest 78: 658–666PubMedCrossRefGoogle Scholar
  9. 9.
    Havel RJ, Chao Y, Windier EE, Kotite L, Guo LSS (1980) Isoprotein specificity in the hepatic uptake of apolipoprotein E and the pathogenesis of familial dysbetalipoproteinemia. Proc Natl Acad Sei USA 77: 4349–4353CrossRefGoogle Scholar
  10. 10.
    Windler EET, Därr WH, Greten H (1986) Removal of chylomicron remnants by the hepatic LDL receptor-possible contribution of the low density lipoprotein receptor. In: Greten H, Windler E, Beisiegel U (eds) Receptor-mediated uptake in the liver. Springer, Berlin Heidelberg New York Tokyo, pp 91–96Google Scholar
  11. 11.
    Hui DY, Brecht WJ, Hall EA, Friedman G, Innerarity TL, Mahley RW (1986) Isolation and characterization of the apolipoprotein E receptor from canine and human liver. J Biol Chem 261: 4256–4267Google Scholar
  12. 12.
    Jones AL, Hradek GT, Hornick C, Renaud G, Windier EET, Havel RJ (1984) Uptake and processing of remnants of chylomicrons and very low density lipoproteins by rat liver. J Lipid Res 25: 1151–1158PubMedGoogle Scholar
  13. 13.
    Greten H, Windler E (1985) Physiologie und Pathophysiologic des Lipoproteinstoffwechsels-Beziehung zu Hyperlipämien und Arteriosklerose. Internist 26: 399–404PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • E. Windler
  • H. Greten

There are no affiliations available

Personalised recommendations