The Extracellular Matrix of the Vessel Wall, Its Role and Modification During the Atherosclerotic Process

  • L. Robert


It is a special pleasure and honour to contribute to this volume dedicated to Prof. Gerhard Schettler for his 70th birthday. Since I entered this field in 1964 I have often had the opportunity of meeting Professor Schettler, listening to his lectures and presenting my results under his presidency. I have especially appreciated his wide interest in every aspect of experimental medicine and biology related to the still wide-open field of atherosclerosis research. In this respect, he certainly deserves to belong to the highly prestigious family of great German physicians who have contributed so much to our understanding of human diseases.


Atherosclerotic Plaque Rabbit Aorta Fibrous Plaque Structural Glycoprotein Atherosclerosis Research 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Robert L, Robert B (1973) Aging of connective tissues-skin. In: Robert L (ed) Frontiers of matrix biology, vol 1. Karger, BaselGoogle Scholar
  2. 2.
    Robert L, Labat-Robert J, Hornebeck W (1987) Aging and atherosclerosis. Atheroscler Rev 14 (in print)Google Scholar
  3. 3.
    Kern P, Sebert B, Robert L (1986) Increased type Ill/type I collagen ratios in diabetic human conjunctival biopsies. Clin Physiol Biochem 4 (2): 113–119PubMedGoogle Scholar
  4. 4.
    Robert L, Robert AM (1980) Elastin, elastase and arteriosclerosis. In: Robert AM, Robert L (eds) Frontiers of matrix biology, vol 8. Karger, Basel, pp 130–173Google Scholar
  5. 5.
    Moczar M, Ouzilou J, Courtois Y, Robert L (1976) Age dependence of the biosynthesis of inter-cellular matrix macromolecules of rabbit aorta in organ culture and cell culture. Gerontology 22: 461–472PubMedCrossRefGoogle Scholar
  6. 6.
    Labat-Robert J, Leutenegger M, Llopis G, Ricard Y, Derouette JC (1984) Plasma and tissue fibronectin in diabetes. Clin Physiol Biochem 2: 39–48PubMedGoogle Scholar
  7. 7.
    Labat-Robert J, Phan Thanh L, Robert L (1985) Modification of plasma and tissue fibronectin in diabetes. In: Reddi AH (ed) Extracellular matrix: structure and function, vol25. Liss, New York, pp 421–426Google Scholar
  8. 8.
    Campbell JH, Campbell GR (1986) The smooth muscle cell. CRC Press, Boca Raton, (in press)Google Scholar
  9. 9.
    Campbell GR, Chamley-Campbell JH (1981) The cellular pathology of atherosclerosis. Pathology 13: 423–440PubMedCrossRefGoogle Scholar
  10. 10.
    Hornebeck W, Tixier JM, Robert L (1986) Inducible adhesion of mesenchymal cells to elastic fibers: elastonectin. Proc Natl Acad Sci USA 83: 5517–5520PubMedCrossRefGoogle Scholar
  11. 11.
    Hornebeck W, Brechemier D, Bourdillon MC, Robert L (1981) Isolation and partial characterization of an elastase-like protease from rat aorta smooth muscle cells. Possible role in the regulation of elastin biosynthesis. Connect Tissue Res 8: 245–249PubMedCrossRefGoogle Scholar
  12. 12.
    Hornebeck W, Derouette JC, Roland J, Chatelet F, Bouissou H, Robert L (1976) Corrélation entre l’âge, l’artériosclérose et l’activité élastinolytique de la paroi aortique humaine. C R Seances Acad Sci 282: 2003–2006Google Scholar
  13. 13.
    Hornebeck W, Brechemier D, Soleilhac JM, Bourdillon MC, Robert L (1985) Studies on rat aorta smooth muscle cells’ elastase activity. In: Reddi AH (ed) Extracellular matrix: structure and function, vol 25. Liss, New York, pp 269–282Google Scholar
  14. 14.
    Senior RM, Griffin GL, Mecham RP (1982) Chemotactic responses of fibroblasts to tropoelastin and elastinderived peptides. J Clin Invest 70: 614–618PubMedCrossRefGoogle Scholar
  15. 15.
    Hornebeck W, Soleilhac JM, Tixier JM, Moczar E, Robert L (1987) Inhibition by elastase inhibitors of the formyl Met Leu Phe-induced Chemotaxis of rat polymorphonuclear leukocytes. Cell Biochem Function (in press)Google Scholar
  16. 16.
    Robert AM, Grosgogeat Y, Reverdy V, Robert B, Robert L (1971) Lésions artérielles produites chez le lapin par immunisation avec l’élastine et les glycoprotéines de structure de l’aorte. Etudes biochimiques et morphologiques. Atherosclerosis 13: 427–449PubMedCrossRefGoogle Scholar
  17. 17.
    Jacob MP, Hornebeck W, Lafuma C, Bernaudin JF, Robert L, Godeau G (1984) Ultrastructural and biochemical modifications of rabbit arteries induced by immunization with soluble elastin peptides. Exp Mol Pathol 41: 171–190PubMedCrossRefGoogle Scholar
  18. 18.
    Stein F, Pezess MP, Robert L, Poullain N (1965) Antielastin antibodies in normal and pathological human sera. Nature 207: 312–313PubMedCrossRefGoogle Scholar
  19. 19.
    Horsch AK, Brechemier D, Robert L, Horsch S (1977) Anti-elastin Antikörper bei der Thrombangiitis obliterans. Verh Dtsch Ges Inn Med 83: 1757–1762Google Scholar
  20. 20.
    Wegrowski J, Moczar M, Robert L (1986) Proteoglycans from pig aorta. Comparative study of their interactions with lipoproteins. Biochem J 235: 823–831PubMedGoogle Scholar
  21. 21.
    Labat-Robert J, Szendroi M, Godeau G, Robert L (1985) Comparative distribution patterns of type I and III collagens and fibronectin in human arteriosclerotic aorta. Pathol Biol 33: 261–265PubMedGoogle Scholar
  22. 21a.
    Adams CWM (1967) Vascular Histochemistry. Lloyd-Luke, LondonGoogle Scholar
  23. 22.
    Jacotot B, Beaumont JL, Monnier G, Szigeti M, Robert B, Robert L (1973) Role of elastic tissue in cholesterol deposition in the arterial wall. Nutr Metab 15: 46–58PubMedCrossRefGoogle Scholar
  24. 23.
    Claire M, Jacotot B, Robert L (1976) Characterization of lipids associated with macromolecules of the intercellular matrix of human aorta. Connect Tissue Res 4: 61–71PubMedCrossRefGoogle Scholar
  25. 24.
    Robert AM, Robert L (eds) (1980) Biology and pathology of elastic tissues. Karger, Basel (Frontiers of matrix biology, vol 8 )Google Scholar
  26. 25.
    Robert L (1980) Mécanismes cellulaires et moléculaires du vieillissement. Masson, ParisGoogle Scholar
  27. 26.
    Kern P, Regnault F, Robert L (1976) Biochemical and ultrastructural study of human diabetic conjunctiva. Biomedecine 24: 32–38PubMedGoogle Scholar
  28. 27.
    Robert AM, Boniface R, Robert L (1979) Biochemistry and pathology of basement membranes. Role in diabetes. Karger, Basel (Frontiers of matrix biology, vol 7 )Google Scholar
  29. 28.
    Kern P, Moczar M, Robert L (1979) Biosynthesis of skin collagens in normal and diabetic mice. Biochem J 182: 337–345PubMedGoogle Scholar
  30. 29.
    Beaumont JL, Grosgogeat Y, Richard JL, Claude JR (1963) La teneur en cholestérol de l’aorte et d’autres organes chez le lapin nourri avec du cholestérol. J Atheroscler Res 3: 210–221CrossRefGoogle Scholar
  31. 30.
    Robert AM, Miskulin M, Godeau G, Tixer JP, Milhaud G (1982) Action of calcitonine on the atherosclerotic modifications of brain microvessels induced in rabbits by cholesterol feeding. Exp Mol Pathol 37: 67–73PubMedCrossRefGoogle Scholar
  32. 31.
    Robert L, Chaudiere J, Jacotot B (1984) Interaction between lipids and the intercellular matrix of the arterial wall: its role in the evolution of atherosclerotic lesions. In: Malinow MR, Blaton VH (eds) Regression of atherosclerotic lesions. Experimental studies and observations in humans. NATO ASI Life Sciences 79: 145–173Google Scholar
  33. 32.
    Moczar M, Lafuma C (1986) Structural glycoproteins from aorta and lung. In: Robert L (ed) Frontiers of matrix biology, vol 11. Karger, Basel, pp 42–57Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • L. Robert

There are no affiliations available

Personalised recommendations