Advertisement

Plasma Levels of Lipoproteins and Apolipoproteins in Octo- and Nonagenarians

  • P. Avogaro
  • G. Bittolo-Bon
  • G. Cazzolato
  • A. Bottecchia
  • R. Brugiolo

Abstract

A great deal of attention has been paid in recent years to high-density lipoproteins (HDL) and to their inverse relationship with the occurrence of ischemic heart disease (IHD). This attention to HDL is not new, as pioneer studies have already emphasized its value as a predictor of “de novo” cases of IHD [1], but it is only recently that a revival of interest in HDL has started, originating from both epidemiological and clinical studies. The seminal paper was by Miller and Miller [2], who stressed the inverse relationship existing between HDL and IHD. At about the same time other papers were published which referred to the existence of families whose members appeared to be protected from IHD by high levels of HDL cholesterol (HDL-C) [3,4,5] and/or of apolipoprotein A (apo A). Furthermore, Glueck et al. [6] proposed that high levels of HDL-C or low levels of low-density lipoprotein cholesterol (LDL-C), or a combination of the two parameters, constitute the features of a “longevity syndrome.” However, data obtained in two subsequent studies [7, 8] do not agree with the proposed biochemical pattern of longevity, although in neither study was the prevalence of hyper-α-lipoproteinemia recorded nor was it ascertained whether any relationship between the mortality rates and the levels of HDL-C existed [8].

Keywords

Lipoprotein Lipase Atherosclerotic Patient Biochemical Pattern High Density Lipoprotein Concentration Sustained Physical Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Gofman JW, Young W, Tandy R (1966) Ischemic heart disease, atherosclerosis and longevity. Circulation 34: 679PubMedGoogle Scholar
  2. 2.
    Miller CJ, Miller NE (1975) Plasma high density lipoprotein concentration and development of ischaemic heart disease. Lancet 1: 16PubMedCrossRefGoogle Scholar
  3. 3.
    Glueck CJ, Fallat RW, Millet F, Steiner PM (1975) Familial hyperalphalipoproteinemia. Arch Int Med 136: 1025CrossRefGoogle Scholar
  4. 4.
    Avogaro P, CazzolatoG (1975) Familial hyper-HDL-(a)-cholesterolemia. Atherosclerosis 22: 63Google Scholar
  5. 5.
    Naito HK, Lewis LA, Mac Cormack LJ, Hofstetter G, Amihanovic J (1975) Hyper-alpha-Lipoproteinemia: a case study. Clin Chem 21: 639PubMedGoogle Scholar
  6. 6.
    Glueck CJ, Gartside PS, Steiner PM, Miller M, Todhunter T, Haof J, Pucke M, Terrana M, Fallat RW, Kastryap ML (1977) Hyperalpha and hypobetalipoproteinemia in octogenarian kindreds. Atherosclerosis 27: 387PubMedCrossRefGoogle Scholar
  7. 7.
    Heckers H, Burkard W, Schmahl FW, Fuhrmann W, Platt D (1982) Hyper-alpha-lipoproteinemia and hypo-beta-lipoproteinemia are not markers for a high life expertancy. Gerontology 28: 176PubMedCrossRefGoogle Scholar
  8. 8.
    Deutscher S, Bates MW, Caines MJ, La Porte RE, Puntereri A, Taylor FH (1986) Determinants of lipid and lipoprotein level in elderly men. Atherosclerosis 60: 221PubMedCrossRefGoogle Scholar
  9. 9.
    Kostner GM, Avogaro P, Bittolo Bon G, Cazzolato G, Quinci GB (1979) Determination of high density lipoproteins: screening methods compared. Clin Chem 25: 939PubMedGoogle Scholar
  10. 10.
    Friedewald TW, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of a preparative ultracentrifuge. Clin Chem 18: 49Google Scholar
  11. 11.
    Laureil CB (1966) Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal Biochem 15: 45CrossRefGoogle Scholar
  12. 12.
    Pococh SJ, Shaper AG, Phillips AN, Walker M, Whitehead TP (1986) High density lipoprotein cholesterol is not a major risk factor for ischaemic heart disease in British men. Br Med J 292: 515CrossRefGoogle Scholar
  13. 13.
    Wood PD, Williams PT, Haskell WL (1984) Physical activity and high-density lipoproteins. In: Miller NE, Miller GJ (eds) Clinical and metabolic aspects of high-density lipoproteins. Elsevier, Amsterdam, pp 133–166Google Scholar
  14. 14.
    Avogaro P, Cazzolato G (1975) Changes in the composition and physicochemical characteristics of serum lipoproteins during ethanol-induced lipaemia in alcoholic subjects. Metabolism 24: 1231PubMedCrossRefGoogle Scholar
  15. 15.
    Mishara BL, Kastenbaum R (1980) Alcohol and old age seminars. In: Greenblatt M (ed) Psychiatry. Academic, LondonGoogle Scholar
  16. 16.
    Ashby P, Bennet DP, Spencer IM, Robinson DS (1978) Post translational regulation of lipoprotein lipase activity in adipose tissue. Biochem J 176: 865PubMedGoogle Scholar
  17. 17.
    Bragby GJ, Lin MS, Spitzer JA (1977) Lipoprotein Lipase activity in rat heart myocites. Life Sei 21: 467CrossRefGoogle Scholar
  18. 18.
    Lithell H, Lindgarde F, Mygaard E, Saltin P (1981) Capillary supply and lipoproteinlipase activity in skeletal muscle in man. Acta Physiol Scand 111: 383PubMedCrossRefGoogle Scholar
  19. 19.
    Ashby P, Robinson DS (1980) Effects of insulin glucocorticoids and adrenaline on the activity of rat adiposetissue lipoprotein lipase. Biochem J 188: 1985Google Scholar
  20. 20.
    Avogaro P, Crepaldi G (1961) Aspetti del metabolismo lipidico nel vecchio. Giorn Gerontol 9: 339Google Scholar
  21. 21.
    Avogaro P, Bittolo Bon G, Cazzolato G, Quinci GB (1979) Are apolipoproteins better discriminators than lipids for atherosclerosis? Lancet 1: 901PubMedCrossRefGoogle Scholar
  22. 22.
    Sniderman AD, Wolfson C, Teng B, Franklin FA, Bachoric PS, Kwiterovich PO (1982) Association of hyperapobetalipoproteinemia with endogenous hypertriglyceridemia and atherosclerosis. Ann Intern Med 97: 833PubMedGoogle Scholar
  23. 23.
    Avogaro P, Bittolo Bon G, Cazzolato G, Quinci GB, Belussi F (1978) Plasma levels of apolipoprotein A–1 and apolipoprotein B in human atherosclerosis. Artery 4: 385Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • P. Avogaro
  • G. Bittolo-Bon
  • G. Cazzolato
  • A. Bottecchia
  • R. Brugiolo

There are no affiliations available

Personalised recommendations