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Graft-Versus-Host-Erkrankung

  • Beatrix Volc-Platzer
  • Klaus Wolff
Conference paper
Part of the Fortschritte der praktischen Dermatologie und Venerologie book series (DERMATOLOGIE, volume 11)

Zusammenfassung

1916 zum ersten Mal als Nebeneffekt bei der Transplantation von Geweben ausgewachsener Hühner auf die Dottersackmembran allogener Hühnerembryonen beobachtet [1] und damals noch abweichend von der heutigen Interpretation gedeutet, ist die Graft-versus-Host-Reaktion (GvH-R) heute von größter Bedeutung. Einerseits stellt sie die Hauptkomplikation therapeutisch durchgeführter Knochenmarktransplantationen (KMT) dar, andererseits umfaßt sie eine Reihe verschiedener Störungen der Immunregulation. Einige dieser Störungen dienen heute als Modelle humaner Erkrankungen, denen ein Autoimmunmechanismus zugrunde liegt.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Beatrix Volc-Platzer
  • Klaus Wolff

There are no affiliations available

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