Arenaviruses pp 145-184 | Cite as

Clearance of Virus by T Lymphocytes Mediating Delayed Type Hypersensitivity

  • O. Marker
  • A. R. Thomsen
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 134)


The mammalian defense system against invading microorganisms has been investigated for more than a hundred years, with the ultimate goal, therapeutically and prophylactically. to overcome human disease caused by infectious agents. Not surprisingly, at present such experimentation focuses considerably on viruses, since these agents do not to any noteworthy degree respond to antibiotics or chemotherapy. In spite of this research, however, it is still uncertain by which mechanisms exactly viruses are cleared from the infected host, and how virus-induced, cell-mediated pathology develops. Although the phenomenon of delayed type hypersensitivity (DTH) — of all the immunologically specific mechanisms believed to be important in virus elimination — was the first to be discovered, it is still far from fully understood.


Delay Type Hypersensitivity Virus Clearance Virus Elimination Lymphocytic Choriomeningitis Lymphocytic Choriomeningitis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin · Heidelberg 1987

Authors and Affiliations

  • O. Marker
    • 1
  • A. R. Thomsen
    • 1
  1. 1.Institute of Medical MicrobiologyCopenhagen UniversityCopenhagen ØDenmark

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