Abstract
Our studies (2–5) towards the structure, kinetics and thermodynamics of DNA hairpins formed in solution by the homologous, (partly-) selfcomplementary DNA fragments d (ATCCTATnTAGGAT), n=0-7, showed that the inherent stability of DNA hairpins is at its maximum when the loop of the hairpin comprises four or five nucleotides. This finding is at variance with earlier experiments (6) which indicated that in RNA hairpins loop lengths of six to seven residues are the most favourable.
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Blommers, M.J.J., Haasnoot, C.A.G. and Hilbers, C.W. (1986) to be published.
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Haasnoot, C.A.G., Blommers, M.J.J., Hilbers, C.W. (1987). Conformational Aspects of Hairpin Loops in DNA Oligonucleotides. In: Ehrenberg, A., Rigler, R., Gräslund, A., Nilsson, L. (eds) Structure, Dynamics and Function of Biomolecules. Springer Series in Biophysics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71705-5_45
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DOI: https://doi.org/10.1007/978-3-642-71705-5_45
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