Conformational Aspects of Hairpin Loops in DNA Oligonucleotides

  • Cornelis A. G. Haasnoot
  • Marcel J. J. Blommers
  • Cornelis W. Hilbers
Conference paper
Part of the Springer Series in Biophysics book series (BIOPHYSICS, volume 1)

Abstract

Our studies (2–5) towards the structure, kinetics and thermodynamics of DNA hairpins formed in solution by the homologous, (partly-) selfcomplementary DNA fragments d (ATCCTATnTAGGAT), n=0-7, showed that the inherent stability of DNA hairpins is at its maximum when the loop of the hairpin comprises four or five nucleotides. This finding is at variance with earlier experiments (6) which indicated that in RNA hairpins loop lengths of six to seven residues are the most favourable.

Keywords

Adenosine Adenine Pyrimidine Thymidine Purine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Cornelis A. G. Haasnoot
    • 1
  • Marcel J. J. Blommers
    • 2
  • Cornelis W. Hilbers
    • 2
  1. 1.Unilever Research LaboratoryVlaardingenThe Netherlands
  2. 2.Laboratory of Biophysical ChemistryUniversity of NijmegenNijmegenThe Netherlands

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