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Conformational Aspects of Hairpin Loops in DNA Oligonucleotides

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Structure, Dynamics and Function of Biomolecules

Part of the book series: Springer Series in Biophysics ((BIOPHYSICS,volume 1))

Abstract

Our studies (2–5) towards the structure, kinetics and thermodynamics of DNA hairpins formed in solution by the homologous, (partly-) selfcomplementary DNA fragments d (ATCCTATnTAGGAT), n=0-7, showed that the inherent stability of DNA hairpins is at its maximum when the loop of the hairpin comprises four or five nucleotides. This finding is at variance with earlier experiments (6) which indicated that in RNA hairpins loop lengths of six to seven residues are the most favourable.

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References

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Author information

Author notes

  1. Cornelis A. G. Haasnoot

    Present address: Unilever Research Laboratory, Olivier van Noortlaan 120, 3133 AT, Vlaardingen, The Netherlands

Authors and Affiliations

  1. Laboratory of Biophysical Chemistry, University of Nijmegen, Toernooiveld, 6525 ED, Nijmegen, The Netherlands

    Marcel J. J. Blommers & Cornelis W. Hilbers

Authors
  1. Cornelis A. G. Haasnoot
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  2. Marcel J. J. Blommers
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  3. Cornelis W. Hilbers
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Editor information

Editors and Affiliations

  1. Department of Biophysics Arrhenius Laboratory, University of Stockholm, S-106 91, Stockholm, Sweden

    Anders Ehrenberg  & Astrid Gräslund  & 

  2. Department of Medical Biophysics, Karolinska Institutet, S-104 01, Stockholm, Sweden

    Rudolf Rigler  & Lennart Nilsson  & 

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© 1987 Springer-Verlag Berlin Heidelberg

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Haasnoot, C.A.G., Blommers, M.J.J., Hilbers, C.W. (1987). Conformational Aspects of Hairpin Loops in DNA Oligonucleotides. In: Ehrenberg, A., Rigler, R., Gräslund, A., Nilsson, L. (eds) Structure, Dynamics and Function of Biomolecules. Springer Series in Biophysics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71705-5_45

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  • DOI: https://doi.org/10.1007/978-3-642-71705-5_45

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71707-9

  • Online ISBN: 978-3-642-71705-5

  • eBook Packages: Springer Book Archive

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