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Conformational Aspects of Hairpin Loops in DNA Oligonucleotides

  • Cornelis A. G. Haasnoot
  • Marcel J. J. Blommers
  • Cornelis W. Hilbers
Part of the Springer Series in Biophysics book series (BIOPHYSICS, volume 1)

Abstract

Our studies (2–5) towards the structure, kinetics and thermodynamics of DNA hairpins formed in solution by the homologous, (partly-) selfcomplementary DNA fragments d (ATCCTATnTAGGAT), n=0-7, showed that the inherent stability of DNA hairpins is at its maximum when the loop of the hairpin comprises four or five nucleotides. This finding is at variance with earlier experiments (6) which indicated that in RNA hairpins loop lengths of six to seven residues are the most favourable.

Keywords

Lower Energy Structure Hairpin Loop Anticodon Loop Imino Proton Adenosine Residue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Cornelis A. G. Haasnoot
    • 1
  • Marcel J. J. Blommers
    • 2
  • Cornelis W. Hilbers
    • 2
  1. 1.Unilever Research LaboratoryVlaardingenThe Netherlands
  2. 2.Laboratory of Biophysical ChemistryUniversity of NijmegenNijmegenThe Netherlands

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