Effects of Pantethine on Experimental Atherosclerosis in Rabbits
Panthetine is the disulfide dimer of panthetheine, the amide conjugate of pantothenic acid and cysteamine, which occurs naturally as a portion of coenzyme A and of acyl-carrier proteins (Wittwer et al. 1985). When pantethine was given to hyperlipopro-teinemic patients, it lowered plasma cholesterol levels (Maioli et al. 1984; Cattin et al. 1985) and elevated high density lipoprotein (HDL) cholesterol levels, especially the HDL2 fraction with a consequent increase in the HDL2/HDL3 ratio (Maioli et al. 1984). The effects on normolipidemic patients were less marked (Murai et al. 1983). In rabbits fed 0.5% cholesterol, pantethine also reduced total cholesterol levels and produced minor decreases in aortic atherosclerosis (Carrara et al. 1984); larger decreases were reported in a study involving a smaller number of animals and the effects were accentuated by combining the intake of pantethine with probucol (Tawara et al. 1986). We have investigated the effects of pantethine and of an ester derivative (tetra[3-(3-pyridinemethoxycarbonyl) propionyl]- pantethine tetratartrate, MG 28362) in rabbits receiving food additioned with cholesterol at the 0.2 or 0.25% level. Only results obtained with pantethine will be reported here.
KeywordsPlasma Cholesterol Aortic Atherosclerosis Experimental Atherosclerosis Lower Plasma Cholesterol Level Amide Conjugate
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