Species Differences in the Metabolic Disposition of Fenofibrate
Fenofibrate (isopropyl 4-(p-chlorobenzoyl)phenoxyisobutyrate: Lipanthyl) is a hypolipidaemic agent structurally related to Clofibrate. In view of current concern over the safety-in-use of this class of drug, there is a need for information about their metabolic disposition, in terms of rates and routes of metabolism and excretion and various factors which might influence these, such as species differences, chronic administration and dose dependency. As an adjunct to both the toxicological evaluation and clinical pharmacological investigation of fenofibrate, we now present the results of a study of its fate in rat, dog and man, and some potential influencing factors.
KeywordsHydrolysis HPLC Albumin Amide Carbonyl
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