The Profile of an HMG-CoA Reductase Inhibitor, CS-514 (SQ 31,000)

Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

Since more than 70% of the total input of body cholesterol is derived from de novo synthesis in humans (Dietschy and Wilson 1970), it is expected that the high level of serum cholesterol can be reduced in consequence of inhibition of cholesterol synthesis. The most desirable target for this inhibition is 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme of cholesterogenesis. ML-236B (also called compactin) was discovered first by Sankyo Co. from the culture broth of a microorganism as a potent competitive inhibitor of HMG-CoA reductase (Endo et al. 1976), and showed remarkable hypolipidemic effect on various experimental animals as well as humans (Kuroda et al. 1979; Tsujita et al. 1979; Yamamoto et al. 1980).

Keywords

Cholesterol Toxicity Triglyceride Prep Penicillium 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Y. Goto
    • 1
  1. 1.Tokai University School of MedicineBohseidai, Isehara, KanagawaJapan

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