The Influence of Terpenes and Analogues on Parameters of Atherosclerosis
Rowachol, a proprietary mixture of the six monoterpenes menthol, menthone, borneol, cineole, camphene and pinene in olive oil, reduced the lithogenicity of bile (Doran et al. 1979) and caused dissolution of cholesterol gallstones in man (Bell and Doran 1979). Daily administration of the drug (6–9 capsules) to 16 patients for periods of 2–28 weeks gave a progressive increase in serum HDL-cholesterol concentration with no accompanying change in the concentrations of serum total cholesterol or triglyceride (Bell et al. 1980) (Fig. 1). Similar effects in humans have been shown recently by Leiss and von Bergmann (1985) who administered Rowachol (200 mg t.i.d) to young healthy volunteers and measured a significant increase in the ratio of HDL-cholesterol to total cholesterol in serum.
KeywordsCholesteryl Ester Cholesterol Gallstone ACAT Activity Serum High Density Lipoprotein Cholesterol Hepatic Cholesterol Synthesis
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