Abstract
Clinical studies orginating from the late 1970s have revealed that compounds which induce hepatic microsomal enzymes may influence hepatic lipid and protein concentrations and increase serum high-density lipoprotein (HDL) levels. They have suggested an approach to prevent the atherosclerotic vascular process. Experimentally, an enzyme inducer has retarded the cholesterol accumulation in the arterial wall and the formation of atherosclerotic plaque. In this chapter I shall concentrate on the effects of microsomal enzyme inducers on liver lipid and protein, and serum HDL-cholesterol (HDL-C) and apolipoprotein concentrations, and the manifestation of atherosclerotic disease in man.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Carlson LA, Kolmodin-Hedman B (1972) Hyper-α-lipoproteinaemia in men exposed to chlorinated hydrocarbon pesticides. Acta Med Scand 192:29–32
Chao YS, Pickett CB, Yamin TT, Guo LS, Alberts AW, Kroon PA (1985) Phenobarbital induces rat liver apolipoprotein A-I mRNA. Mol Pharmacol 27:394–398
Durrington PN (1979) Effect of phenobarbitone on plasma apolipoprotein B and plasma high-density lipoprotein cholesterol in normal subjects. Clin Sci 56:501–503
Greim HA (1981) An overview of the phenomena of enzyme induction: their relevance to drug action and interactions. In: Jenner B, Testa B (eds) Concepts in drug metabolism, Pt B. Dekker, New York, pp 219–263
Luoma PV (1986) Enzyme inducers. In: Fears R (ed) Pharmacological control of hyperlipidaemia. Prous, Barcelona, pp 365–376
Luoma PV, Pelkonen RO, Sotaniemi EA (1979) Plasma high-density lipoprotein cholesterol and hepatic drug metabolizing enzyme activity in man. Acta Physiol Scand Suppl 473:226A
Luoma PV, Sotaniemi EA, Pelkonen RO, Savolainen MJ, Ehnholm C (1982) Induction and lipoproteins. Lancet 1:625
Muuronen A, Kaste M, Nikkilä EA, Tolppanen E-M (1985) Mortality from ischaemic heart disease among patients using anticonvulsive drugs: case-control study. Br Med J 291:1481–1483
Nikkilä EA, Taskinen M-R, Jane T (1987) Plasma high-density lipoprotein concentration and subfraction distribution in relation to triglyceride metabolism. Amer Heart J 113:543–548
Salvador RA, Atkins C, Haber S, Kozma C, Conney AH (1970) Effect of phenobarbital on the development of atheromatosis in the cholesterol-fed rabbit. Biochem Pharmacol 19:1975–1981
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Luoma, P.V. (1987). Enzyme-Inducers and High-Density Lipoproteins. In: Paoletti, R., Kritchevsky, D., Holmes, W.L. (eds) Drugs Affecting Lipid Metabolism. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71702-4_38
Download citation
DOI: https://doi.org/10.1007/978-3-642-71702-4_38
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71704-8
Online ISBN: 978-3-642-71702-4
eBook Packages: Springer Book Archive