Abstract
Evaluating a new drug for the first time in patients requires knowledge of clinical trial methodology, the pharmacology of the drug, and the clinical condition being treated. When the new drug is designed to modify blood lipids this undertaking is complicated by many factors and circumstances affecting the accurate determination of safety and efficacy parameters in hyperlipidemic patients.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Dujovne CA, Weiss P, Bianchine JR (1971) Comparative clinical therapeutic trial with two hypolipidemic drugs, Clofibrate and nafenopin (SU-13437). Clin Pharmacol Ther 12:117–125
Dujovne CA, Hurwitz A, Kauffman RE, Azarnoff DL (1974) Colestipol and Clofibrate in hypercholesterolemia. Clin Pharmacol Ther 16:291–296
Dujovne CA, Azarnoff DL, Pentikainen P, Manion C, Hurwitz A, Hassanein K (1976) A two-year crossover therapeutic trial with halofenate and Clofibrate. Am J Med Sci 272:277–284
Dujovne CA, Azarnoff DL, Pentikainen P, Manion C, Hurwitz A (1979) Clofibrate and nicotinyl alcohol tartrate in hyperlipoproteinemic patients. Am J Med Sci 277:255–261
Dujovne CA, Chernoff S, Krehbiel P, Jackson B. DeCoursey S, Taylor H (1984a) Low dose colestipol plus probucol for hypercholesterolemia. Am J Cardiol 53:1515–1518
Dujovne CA, DeCoursey S, Krehbiel P, Jackson B, Chernoff S (1984b) Serum lipids in normo- or hyperlipidemics after methyldopa or propranolol therapy. Clin Pharmacol Ther 36:157–162
Dujovne CA, Krehbiel P, DeCoursey S, Jackson B, Chernoff S, Pitterman A, Garty M (1984c) Probucol plus colestipol in treatment of hypercholesterolemia. Ann Int Med 100:477–482
Dujovne CA, Krehbiel P, Chernoff SB (1986) Controlled studies of the efficacy and safety of combined probucol-colestipol therapy. Am J Cardiol 57:36H–42H
Jackson B, Dujovne CA, DeCoursey S, Beyer P, Brown EF, Hassanein K (1986) Method to assess dietary compliance in outpatient clinical trials. J Am Diet Assoc (November 1986) 86:1531–1535
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Dujovne, C.A., Krehbiel, P. (1987). Considerations for Controlled Clinical Testing of Safety and Efficacy of New Hypolipidemic Drugs. In: Paoletti, R., Kritchevsky, D., Holmes, W.L. (eds) Drugs Affecting Lipid Metabolism. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71702-4_25
Download citation
DOI: https://doi.org/10.1007/978-3-642-71702-4_25
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71704-8
Online ISBN: 978-3-642-71702-4
eBook Packages: Springer Book Archive