Advertisement

Cellular and Molecular Biology of Apolipoproteins: Receptor-Mediated Regulation of Cholesterol Metabolism

  • R. W. Mahley
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

Lipoprotein receptors, especially those within the liver, play a central role in the regulation of cholesterol metabolism. Specific apolipoproteins (apo-) serve as the ligands for these receptors (for review, see Brown and Goldstein 1983, 1986; Mahley and Innerarity 1983; Mahley et al. 1984).

Keywords

Cholesterol Metabolism Lipoprotein Receptor Cholesterol Homeostasis Chylomicron Remnant Human Apolipoprotein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Blackhart BD, Ludwig EH, Pierotti VR, Caiati L, Onasch MA, Wallis SC, Powell L, Pease R, Knott TJ, Chu ML, Mahley RW, Scott J, McCarthy BJ, Levy-Wilson B (1986) Structure of the human apolipoprotein B gene. J Biol Chem 261:15364–15367PubMedGoogle Scholar
  2. Brown MS, Goldstein JL (1983) Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic. J Clin Invest 72:743–747PubMedCrossRefGoogle Scholar
  3. Brown MS, Goldstein JL (1986) A receptor-mediated pathway for cholesterol homeostasis. Science 232:34–47PubMedCrossRefGoogle Scholar
  4. Hui DY, Innerarity TL, Mahley RW (1981) Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors. J Biol Chem 256:5646–5655Google Scholar
  5. Hui DY, Brecht WJ, Hall EA, Friedman G, Innerarity TL, Mahley RW (1986a) Isolation and characterization of the apolipoprotein E receptor from canine and human liver. J Biol Chem 261:4256–4267PubMedGoogle Scholar
  6. Hui DY, Hall EA, Brecht WJ, Innerarity TL, Mahley RW (1986b) Molecular cloning and identification of the ligand binding domain of the human apolipoprotein E receptor. Arteriosclerosis 6:551aGoogle Scholar
  7. Innerarity TL, Friedlander EJ, Rall SC, Jr, Weisgraber KH, Mahley RW (1983) The receptor binding domain of human apolipoprotein E: binding of apolipoprotein E fragments. J Biol Chem 258:12341–12347Google Scholar
  8. Innerarity TL, Weisgraber KH, Arnold KS, Ral SC, Jr, Mahley RW (1984) Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation. J Biol Chem 259:7261–7267PubMedGoogle Scholar
  9. Knott TJ, Rall SC, Jr, Innerarity TL, Jacobson SF, Urdea MS, Levy-Wilson B, Powell LM, Pease RJ, Eddy R, Nakai H, Byers M, Priestley LM, Robertson E, Rall LB, Betsholtz C, Shows TB, Mahley RW, Scott J (1985) Human apolipoprotein B: structure of carboxyl-terminal domains, sites of gene expression, and chromosomal localization. Science 230:37–43PubMedCrossRefGoogle Scholar
  10. Knott TJ, Pease RJ, Powell LM, Wallis SC, Rall SC, Jr, Innerarity TL, Blackhart B, Taylor WR, Lusis AJ, McCarthy BJ, Mahley RW, Levy-Wilson B, Scott J (1986) Human apolipoprotein B: complete cDNA sequence and identification of structural domains of the protein. Nature (London) 323:734–738CrossRefGoogle Scholar
  11. Mahley RW, Innerarity TL (1983) Lipoprotein receptors and cholesterol homeostasis. Biochim Biophys Acta 737:197–222PubMedGoogle Scholar
  12. Mahley RW, Hui DY, Innerarity TL, Weisgraber KH (1981) Two independent lipoprotein receptors on hepatic membranes of the dog, swine, and man. Apo-B,E and apo-E receptors. J Clin Invest 68:1197–1206PubMedCrossRefGoogle Scholar
  13. Mahley RW, Innerarity TL, Rall SC, Jr, Weisgraber KH (1984) Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res 25:1277–1294PubMedGoogle Scholar
  14. Mahley RW, Innerarity TL, Rall SC, Jr, Weisgraber KH (1985) Lipoproteins of special significance in atherosclerosis: insights provided by studies of type III hyperlipoproteinemia. Ann NY Acad Sci 454:209–221PubMedCrossRefGoogle Scholar
  15. Vogel T, Weisgraber KH, Zeevi MI, Ben-Artzi H, Levanon AZ, Rall SC, Jr, Innerarity TL, Hui DY, Taylor JM, Kanner D, Yavin Z, Amit B, Aviv H, Gorecki M, Mahley RW (1985) Human apolipoprotein E expression in Escherichia coli: structural and functional identity of the bacterially produced protein with plasma apolipoprotein E. Proc Natl Acad Sci USA 82:8696–8700CrossRefGoogle Scholar
  16. Weisgraber KH, Innerarity TL, Harder KJ, Mahley RW, Milne RW, Marcel YL, Sparrow JT (1983) The receptor binding domain of human apolipoprotein E: monoclonal antibody inhibition of binding. J Biol Chem 258:12348–12354PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • R. W. Mahley
    • 1
    • 2
  1. 1.The Gladstone Foundation Laboratories for Cardiovascular Disease, Cardiovascular Research Institute, Department of PathologyUniversity of CaliforniaSan FranciscoUSA
  2. 2.The Gladstone Foundation Laboratories for Cardiovascular Disease, Cardiovascular Research Institute, Department of MedicineUniversity of CaliforniaSan FranciscoUSA

Personalised recommendations