Functional Analysis of the ras-Related YPT1 Gene Product in Yeast

  • D. Gallwitz
  • R. Brökel
  • C. M. T. Molenaar
  • A. J. G. Rauh
  • H. D. Schmitt
  • P. Wagner
Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie 10.–12. April 1986 in Mosbach/Baden book series (MOSBACH, volume 37)

Abstract

H-ras, K-ras and N-ras are members of a family of highly homologous vertebrate proto-oncogenes that code for a protein of 189 amino acids. The p21 protein products of the viral v-H-ras and v-K-ras genes are the causing agents of rat sarcomas and mutated forms of all three ras proto-oncogenes have been shown to be contained in several human tumours and tumour cell lines and to be able to transform malignantly NIH3T3 fibroblasts ((1,2) for review).

Keywords

Filtration Recombination Cysteine Electrophoresis Germinate 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bishop JM (1985) Trends Genet 1:245–249CrossRefGoogle Scholar
  2. 2.
    Levinson AD (1986) Trends Genet 2:81–85CrossRefGoogle Scholar
  3. 3.
    Gibbs JB, Sigal IS, Scolnick EM (1985) Trends Biochem Sci 10:350–353CrossRefGoogle Scholar
  4. 4.
    Gallwitz D, Donath C, Sander C (1983) Nature (London) 306:704–707CrossRefGoogle Scholar
  5. 5.
    DeFeo-Jones D, Scolnick EM, Koller R, Dhar R (1983) Nature (London) 306:707–709CrossRefGoogle Scholar
  6. 6.
    Powers S, Kataoka T, Fasano O, Goldfarb M, Strathern J, Broach J, Wigler M (1984) Cell 36:607–612PubMedCrossRefGoogle Scholar
  7. 7.
    Toda T, Uno I, Ishikawa T, Powers S, Kataoka T, Broek D, Cameron S, Broach J, Matsumoto K, Wigler M (1985) Cell 40:27–36PubMedCrossRefGoogle Scholar
  8. 8.
    Uno I, Mitzusawa H, Matsumoto K, Tanaka K, Oshima T, Ishikawa T (1985) Proc Natl Acad Sci USA 82:7855–7859PubMedCrossRefGoogle Scholar
  9. 9.
    Beckner SK, Hattori S, Shih TY (1985) Nature (London) 317:71–72CrossRefGoogle Scholar
  10. 10.
    Birchmeier C, Broek D, Wigler M (1985) Cell 43:615–621PubMedCrossRefGoogle Scholar
  11. 11.
    Birchmeier C, Broek D, Wigler M (1985) Cell 43:615–621Google Scholar
  12. 12.
    Murray AW, Szostak JW (1983) Cell 34:961–970PubMedCrossRefGoogle Scholar
  13. 13.
    Halliday K (1984) J Cyclic Nucleotide Prot Phosphoryl Res 9:435–448Google Scholar
  14. 14.
    Möller W, Amons R (1985) FEBS Lett 186:1–7PubMedCrossRefGoogle Scholar
  15. 15.
    Tanabe T, Nukada T, Nishikawa Y, Sugimoto K, Suzuki H, Takahashi H, Noda M, Haga T, Ichiyama A, Kangawa K, Minamino N, Matsuo H, Numa S (1985) Nature (London) 315:242–245CrossRefGoogle Scholar
  16. 16.
    Jurnak F (1985) Science 230:32–36PubMedCrossRefGoogle Scholar
  17. 17.
    Fasano O, Aldrich T, Tamanoi F, Taparowsky E, Furth M, Wigler M (1984) Proc Natl Acad Sci USA 81:4008–4012PubMedCrossRefGoogle Scholar
  18. 18.
    Seeburg PH, Colby WW, Capon JJ, Goeddel DV, Levinson AD (1984) Nature (London) 314:71–74CrossRefGoogle Scholar
  19. 19.
    Yuasa Y, Srivastava SK, Dunn CY, Rhim JS, Reddy EP, Aaranson SA (1983) Nature (London) 303:775–779CrossRefGoogle Scholar
  20. 20.
    Der CJ, Finkel T, Cooper GM (1986) Cell 44:167–176PubMedCrossRefGoogle Scholar
  21. 21.
    Shih TY, Stokes PE, Smythers GV, Dhar R, Oroszian S (1982) J Biol Chem 257:11776–11773Google Scholar
  22. 22.
    McCormick F, Clark BFC, La Cour TFM, Kjelgaard M, Norskov-Lauritsen L, Nijborg J (1985) Science 230:78–82PubMedCrossRefGoogle Scholar
  23. 23.
    Gibbs JB, Sigal IS, Poe M, Scolnick EM (1984) Proc Natl Adad Sci USA 81:5704–5708CrossRefGoogle Scholar
  24. 24.
    Kataoka T, Powers S, Cameron S, Fasano O, Goldfarb M, Broach J, Wigler M (1985) Cell 40:19–26PubMedCrossRefGoogle Scholar
  25. 25.
    DeFeo-Jones D, Tatchell K, Robinson LC, Sigal IS, Vass WC, Lowy DR, Scolnick EM (1985) Science 228:179–184PubMedCrossRefGoogle Scholar
  26. 26.
    Fukui Y, Kozasa T, Kaziro Y, Takeda T, Yamamoto M (1986) Cell 44:329–336PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • D. Gallwitz
  • R. Brökel
  • C. M. T. Molenaar
  • A. J. G. Rauh
  • H. D. Schmitt
  • P. Wagner
    • 1
  1. 1.Physiologisch-Chemisches InstitutUniversität MarburgMarburgGermany

Personalised recommendations