Cell Cycle Genes as Potential Oncogenes
The control of cellular proliferation in animal cells is regulated by growth factors and by the cellular genes and gene products that respond to the growth factors. The search for genes and gene products that control cell reproduction began more than 20 years ago with the pioneering experiments of Lieberman et al. (1963), and of Baserga et al. (1965). These early experiments, based on the use of inhibitory drugs like actinomycin D, have been previously reviewed (Baserga 1978, 1985). More recently, a formal demonstration was obtained that RNA polymerase II-directed transcripts are necessary for the entry of quiescent cells into S phase (Rossini et al. 1980, Baserga et al. 1982). It is therefore reasonable to search for genes transcribed by RNA polymerase II that control cell proliferation in animal cells.
KeywordsCell Cycle Gene Rous Sarcoma Virus Cell Proliferation Gene Senescent Human Diploid Fibroblast Cell Cycle Dependent Gene
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