Skip to main content
SpringerLink
Log in

Polyklonale B-Zellaktivierung bei schwerer Hämophilie A

  • Conference paper
16. Hämophilie-Symposion

  • 15 Accesses

Zusammenfassung

Das „acquired immunodeficiency Syndrome“ (AIDS) ist vornehmlich auf bestimmte Risikogruppen beschränkt [24]. Für Patienten mit Hämophilie A und Faktorsubstitution wird eine Erkrankungsinzidenz von 0,8% angegeben [5]. Bei einem Großteil der Hämophiliepatienten lassen sich Antikörper gegen das HTLV III-Virus nachweisen. Wie für das AIDS-Vollbild sind bei der Hämophilie neben Defekten der zellulären Immunantwort auch Störungen der B-Lymphozytenfunktion festgestellt worden [1, 23].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Brieva JA, Sequi J, Zabay JM, Pardo A, Campos A, Luz de la Sen M, Bootello A (1985) Abnormal B-cell function in haemophiliacs and their relationship with factor concentrates administration. Clin Exp Immunol 59: 491

    PubMed  CAS  Google Scholar 

  2. Chen W-Y, Fudenberg HH (1982) Polyclonal activation of human peripheral blood B-lymphocytes. III. Cellular interaction and immunoregulation of immunoglobulin-secreting cells induced by formaldehyd-fixed Salmonella paratyphy B. Clin Immunol Immunopathol 22: 279

    Article  PubMed  CAS  Google Scholar 

  3. Gross WL (1982) Lymphozytenantwort auf humanpathogene Streptokokkenantigenpräparationen. Thieme Copythek, Thieme, Stuttgart New York

    Google Scholar 

  4. Gross WL, Rucks A (1983) Klebsiella pneumoniae stimulate highly purified human blood B-cells to mature into plaque forming cells without prior proliferation. Clin Exp Immunol 52: 372

    PubMed  CAS  Google Scholar 

  5. Jones P (1983) Acquired immunodeficiency Syndrome, hepatitis, and haemophilia. Brit Med J 287: 1737

    Article  CAS  Google Scholar 

  6. Kekow J, Sieg J, van de Venn D, Gross WL (1984) Regulation of B -cell activity in man induced by T-cell dependent and “true” polyclonal B-cell activators. I. Role of suppressor cells. 14. Leukozytenkulturen Konferenz, Hamburg, März 1984

    Google Scholar 

  7. Kekow J, Kern P, Dietrich M, Gross WL (1985) T- und B-Zellreaktionen bei AIDS und AIDS- Risikogruppen. Immun Infekt 13: 26

    PubMed  CAS  Google Scholar 

  8. Kekow J, Kern P, Schmitz H, Gross WL (1986) Abnormal B-cell response to T-cell independent polyclonal B-cell activators in homosexuals presenting persistent generalized lymph node enlargement and HTLV III antibodies. Diagn Immunol 4: 107

    PubMed  CAS  Google Scholar 

  9. Kekow J, Kern P, Gross WL (1986) B-cell reactivity in homosexuals with persistent generalized lyphadenopathy (PGL). CDP 9 (in press)

    Google Scholar 

  10. Kekow J, Plendl H, Gross WL (1986) Abnormal B-cell response to T-cell independent polyclonal B-cell activators in haemophilia A. Clin Exp Immunol 64: 376

    PubMed  CAS  Google Scholar 

  11. Kekow J, Plendl H, Gross WL (1986) Influence of factor substitution on the B-cell response in hemophiliacs. CDP 9 (in press)

    Google Scholar 

  12. Kitchen LW, Barin F, Sullivan JL, McLane MF, Brettler DB, Levine PH, Essex M (1984) Aetiology of AIDS-antibodies to human T-cell leucaemia virus (type III) in haemophiliacs. Nature 312: 367

    Article  PubMed  CAS  Google Scholar 

  13. Lane HC, Masur H, Edgar LC, Whalen G, Rook AH, Fauci AS (1983) Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency Syndrome. N Engl J Med 309: 453

    Article  PubMed  CAS  Google Scholar 

  14. Lechner K, Niessner H, Bettelheim P, Deutsch E, Fasching I, Fuhrmann M, Hinterberger W, Korninger C, Neumann E, Liszka K, Knapp W, Mayr WR, Stingl G, Zeitlhuber U (1983) T-cell alterations in haemophiliacs treated with commercial clotting factor concentrates. Thromb Haemostas 50: 553

    Google Scholar 

  15. Lederman MM, Ratnoff OD, Scillan JJ, Jones PK, Schacter B (1983) Impaired cell-mediated immunity in patients with classic haemophilia. N Engl J Med 308: 79

    Article  PubMed  CAS  Google Scholar 

  16. Longo DL, Gelmann EP, Cossman J, Young RA, Gallo RC, O’Brian SJ, Matis LA (1984) Isolation of HTLV-transformed B-lymphocyte clone from a patient with HTLV-associated adult T-cell leucaemia. Nature 310: 505

    Article  PubMed  CAS  Google Scholar 

  17. Montagnier L, Gruest J, Charmaret S, Dauguet C, Acler C, Guétard D, Nugeyre MT, Barré- Sinoussi F, Chermann J-C, Brunet JB, Klatzmann D, Gluckman JC (1984) Adaptation of lymphadenopathy associated virus ( LAV) to replication in EBV-transformed B lymphoblastoid cell lines. Science 225: 63

    Article  PubMed  CAS  Google Scholar 

  18. Mosier DE, Yetter RA, Morse HC (1985) Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult CS7 B1/6 mice. J Exp Med 161: 766

    Article  PubMed  CAS  Google Scholar 

  19. Quinn TC (1984) Early symptoms and signs of AIDS and the AIDS-related complex. In: Ebbesen P, Biggar RJ, Melbye M (eds) AIDS. Munksgaard, Copenhagen

    Google Scholar 

  20. Sarngadharan MG, Popovic M, Bruch L, Schüpbach J, Gallo RC (1984) Antibodies reactive with human T-lymphotrophic retroviruses ( HTLV-III) in the serum of patients with AIDS. Science 224: 506

    Article  PubMed  CAS  Google Scholar 

  21. Schneider H, Sutor AH, Thaiss H, Künzer W (1984) Alterations of T-cell subsets in hemophiliacs during treatment. Blut 49: 225

    Google Scholar 

  22. Schuurman RKB, Gelfand EW, Dosch H-M (1980) Polyclonal activation of human lymphocytes in vitro. I. Characterisation of the lymphocyte response to a T-cell-independent B-cell mitogen. J Immunol 125: 820

    PubMed  CAS  Google Scholar 

  23. Seki H, Taga K, Nagaoki T, Barot-Ciorbaru R, Miyawaki T, Taniguchi N (1985) Some evidence for the in vivo functional activation of suppressor T-cells in asymptomatic patients with hemophilia A receiving factor VIII concentrates. Clin Immunol Immunopathol 34: 27

    Article  PubMed  CAS  Google Scholar 

  24. Seligmann M, Chess L, Fahey JL, Fauci AS, Lachmann PJ, L’Age-Stehr J, Ngu J, Pinching AJ, Rosen FS, Spira TJ, Wybran J (1984) AIDS — And immunologic reevaluation. N Engl J Med 311: 1286

    Article  PubMed  CAS  Google Scholar 

  25. Tsoukas C, Gervais F, Shuster J, Gold P, O’Shaughnessy M, Robert-Guroff M (1984) Association of HTLV-III antibodies and cellular immune status of haemophiliacs. N Engl J Med 311: 1514

    Article  PubMed  CAS  Google Scholar 

  26. Voller A, Bartlett A, Bidwell D (1978) Enzyme immunoassay with special reference to ELISA techniques. J Clin Path 31: 507

    Article  PubMed  CAS  Google Scholar 

  27. Volsky DJ, Sinangil F, Sonnabend J, Casareale D (1985) Isolation of HTLV-III and EBV- positive B lymphoblastoid cell lines from peripheral blood lymphocytes of AIDS patients. Ann Intern Med (in press)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Kiel, Germany

    J. Kekow, H. Plendl, W. Grote, H. D. Bruhn, F. Asbeck & W. L. Gross

Authors
  1. J. Kekow
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Plendl
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. Grote
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. D. Bruhn
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. Asbeck
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. W. L. Gross
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Abteilung Hämatologie und Onkologie, Universität-Kinderklinik, Martinistraße 25, 2000, Hamburg 20, Germany

    G. Landbeck

  2. 8000, München, Germany

    R. Marx

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Kekow, J., Plendl, H., Grote, W., Bruhn, H.D., Asbeck, F., Gross, W.L. (1987). Polyklonale B-Zellaktivierung bei schwerer Hämophilie A. In: Landbeck, G., Marx, R. (eds) 16. Hämophilie-Symposion. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71682-9_28

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71682-9_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17244-4

  • Online ISBN: 978-3-642-71682-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation