Abstract
Patients with hemophilia have been reported to suffer from a series of immune dysfunctions in cellular and humoral immunity. In addition to “antigen overload” induced phenomena resulting from factor VIII and factor IX substitution, possibly via alloantigen “contamination” in the preparations, latent viral infections such as CMV, hepatitis B and non A/non B have been proposed as the responsible parameters (cf. [1] for review). The discovery of antibodies to LAV1/HTLV III in a group of these patients has sparked the discussion as to whether this type of virus contributes significantly to the pathogenesis of the immune system [2]. In contrast to the increasing percentage of hemophilia patients who have developed AIDS or AIDS-related symptoms from 1981/1982 to October 1984 [3], most recent studies indicate that the number of the cases of AIDS reported in hemophiliacs are not increasing as rapidly as those for other risk groups such as homosexuals, i. v. drug abusers, and their heterosexual partners [4–6]. Since the viral propagation in vivo is definitely related to the number of activated OKT4 positive T-cells [7], patients suffering from other multiple infections of viral, bacterial, or fungal origin are at highest risk to develop LAV1-induced immunodeficiency. This seems to be generally applicable to hemophiliacs as well. Furthermore, generalized lymphadenopathy has been reported in a number of hemophiliacs, however without direct evidence for LAV1 harboring in lymph node cells [8,9].
Preview
Unable to display preview. Download preview PDF.
References
Ragni MV, Lewis JH, Spero JA, Bontempo FA, Rabin BS (1984) Decreased helper/suppressor cell ratios after treatment with factor VIII and IX concentrates and fresh frozen plasma. AM J Med 76:206
Goldsmith JC, Moseley PL, Monick M, Brady M, Hunninghake GW (1983) T-lymphocyte subpopulation abnormalities in apparently healthy patients with hemophilia. Ann In Med 98:294
Gürtler LG, Wernicke D, Eberle J, Zoulek G, Deinhardt F, Schramm W (1984) Increase in prevalance of anti-HTLV III in haemophiliacs. Lancet December 1:1275
Kitchen LW, Barin F, Sullivan JL et al. (1984) Aetiology of AIDS: Antibodies to human T-cell leukaemia virus (type III) in haemophiliacs. Nature 312:367
Evatt BL, Gomperts ED, McDougal JS et al. (1985) Coincidental appearance of LAV I/HTLV III antibodies in hemophiliacs and the onset of the AIDS epidemic. N Engl J Med 312:483
Eyster ME, Goedert JJ, Sarngadharan MG, Weiss SH, Gallo RC, Blattner WA (1985) Development and early natural history of HTLV III antibodies in persons with hemophilia. JAMA 253:2219
Montagnier L et al. (1984) A new human T-lymphotropic retrovirus: characterization and possible role in lymphadenopathy and acquired immune deficiency syndromes. In: Human T-cell leukemia lymphoma viruses. (Ed: Gallo RC, Essex M, Gross L.) Cold Spring Harbour, New York, p 363
Andes WA, deShazo RD, Reed RJ, Harkin JC, Wang NNS (1984) Studies of lymph nodes from patients with classical hemophilia. Blood 64:768
Ragni MV, Winkelstein A, Evans TL, Lewis JH, Bontempo FA, Spero JA, Rabin BS (1984) T-lymphocyte colony assay in hemophiliacs. Blood 64:105
Wernet P, Muller CP, Ostendorf P (1984) Reactivity of lymphocytic and myelocytic leukemia blasts with monoclonal antibodies specific for the different human class II molecules. Disease Markers 2:449
Schneider EM, Pawelec GP, Shi LR, Uchanska-Ziegler B, Burning HJ, Wernet P (1984) TÜ69, a new monoclonal antibody to the human interleukin 2 receptor. I. Specificity and inhibitory activity for T-cell function, submitted
Pawelec GP, Hadam MR, Ziegler A et al. (1982) Long term culture, cloning, and surface markers of mixed lymphocyte-derived human T-lymphocytes with natural killer-like cytotoxicity. J Immunol 128:1892
Popovic M, Sarngadharan MG, Reed E et al. (1984) Detection, isolation, and continuous production of cytopathic human T-lymphotropic retrovirus (HTLV III) from patients with AIDS and pre-AIDS. Science 224:497
Sarin PS, Aoki T, Shibata A et al. (1983) High incidence of human type-C retrovirus (HTLV) in family members of a HTLV-positive Japanese T-cell leukemia patient. Proc Natl Acad Sci 80:2370
Gill JC, Menitove JE, Dana W, Wheeler D, Aster RH, Montgomery RR (1983) Generalized lymphadenopathy and T-cell abnormalities in hemophilia A. J Pediatr 103:18
Nicholson JKA, McDougal JS, Spira TJ, Cross GD, Jones BM, Reinherz EL (1983) Immuno-regulatory subsets of the T-helper and T-suppressor cell population in homosexual men with chronic unexplained lymphadenopathy. J Clin Invest 73:191
Miyakoshi H, Koide H, Aoki T (1984) In vitro antibody-dependent cellular cytotoxicity against human T-cell leukemia/lymphoma virus (HTLV)-producing cells. Int J Cancer 33:287
Gatenbfy PA, Kansas GS, Xian CY, Evans RL, Engleman EG (1982) Dissection of immuno-regulatory subpopulations of T-lymphocytes within the helper and suppressor sublineages in man. J Immunol 129:1997
Sasportes M, Wollmann E, Cohen D, Carosella E, Bensussan A, Fradelizi D, Dausset J (1980) Suppression of the human allogeneic response in vitro with primed lymphocyte and suppressive supernatants. J Exp Med 152:270
Armstrong JA, Dawkins RL, Horne R (1985) Retroviral infection of accessory cells and the immunological paradox in AIDS. Immunology Today 6:121
Klatzmann D, Champagne E, Chamaret S, Gruest J, Guetard D, Hercend T, Gluckman J-C, Montagnier L (1984) T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature 312:767
Dalgleish AG, Beverly PCL, Clapham PR, Crawford DH, Greaves MF, Weiss RA (1984) The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312:763
Hasset JM, Zaroulis CG, Greenberg ML, Siegal FP (1983) Bone marrow transplantation in AIDS. N Engl J Med 309:665
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Schneider, E.M. et al. (1986). Surface Marker Data and Functional Analysis of Hemophilia Patients with and without Antibodies to LAV1. In: Landbeck, G., Marx, R. (eds) 2. Rundtischgespräch Therapiebedingte Infektionen und Immundefekte bei Hämophilen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71664-5_20
Download citation
DOI: https://doi.org/10.1007/978-3-642-71664-5_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-17231-4
Online ISBN: 978-3-642-71664-5
eBook Packages: Springer Book Archive