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What Can We Learn about the Acetylcholine Receptor from Synthetic Peptides?

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Nicotinic Acetylcholine Receptor

Part of the book series: NATO ASI Series ((ASIH,volume 3))

Abstract

The nicotinic acetylcholine receptor (AChR) is a well characterized neurotransmitter receptor and transmembrane ionic channel. It is composed of five subunits in a stoichiometry of α2ßγδ (for reviews see 1–3). The AChR from electric fish has been isolated and the amino acid sequence of the subunits have been deduced by recombinant DNA technology (4–8). The strong homology between the Torpedo AChR and AChR from skeletal muscle of other species made it possible to clone and deduce the sequence of the receptor from muscle tissue, where its amount is 3–4 orders of magnitude lower than that of the Torpedo electric organ (9–13). The sequence data have been the basis for predictions concerning the transmembrane orientation of the AChR subunits, as well as the possible location of the acetylcholine binding site, the glycosylation and phosphorylation sites, and the main immunogenic determinants.

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Author information

Authors and Affiliations

  1. Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel

    Sara Fuchs, Drorit Neumann & Anat Safran

Authors
  1. Sara Fuchs
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  2. Drorit Neumann
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  3. Anat Safran
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Editor information

Editors and Affiliations

  1. Max-Planck-Institut für Ernährungsphysiologie, Rheinlanddamm 201, D-4600, Dortmund, Germany

    Alfred Maelicke

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Fuchs, S., Neumann, D., Safran, A. (1986). What Can We Learn about the Acetylcholine Receptor from Synthetic Peptides?. In: Maelicke, A. (eds) Nicotinic Acetylcholine Receptor. NATO ASI Series, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71649-2_5

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  • DOI: https://doi.org/10.1007/978-3-642-71649-2_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71651-5

  • Online ISBN: 978-3-642-71649-2

  • eBook Packages: Springer Book Archive

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