Abstract
In the present paper, the structure of the acetylcholine receptor molecule (AChR) is described which has been obtained by the analysis of a large number of electron microscopical images of this molecule. In contrast to previous papers [1,2,3] here a new method of image processing of a large number of noisy molecules is used. Instead of the usual staining with uranyl salts, phosphotungstate is applied.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Zingsheim, H.P. Neugebauer, D.C., Barranted, F.J. and Frank, J. (1980) Proc. Natl. Acad. Sci. USA 77, 952–956
Zingsheim, H.P., Barranted, F.J. Frank, J. Hänicke, W. and Neugebauer, D.C. (1982) Nature 299, 81–84
Brisson, A. and Unwin, P.N.T. (1985) Nature 315 No. 6019, 474–477
Kunath, W., Sack-Kongehl, H. and Giersig, M., Int. Symposium on Electron Optics, Beijing (ISEOB), Sept. 1986
Schmidt, J. and Raftery, M.A. (1974) J. Neurochem. 23, 617–622
Changeux, J.P., Devillers-Thiévy, A., Chemouilli, P. (1984) Science Vo. 225, 1335–1345
Reinhardt, S., Schmiady, H., Tesche, B. and Hucho, F. (1984) FEBS Lett. 173, 217–221
Hucho, F. and Changeux, J.P. (1973) FEBS Lett. 38, 145
Hucho, F., Bandini, G. and Suarez-Isla, B.A. (1978) Eur. J. Biochem. 83, 335–340
Reynolds, J. and Karlin, A. (1978) Biochemistry 17, 2035–2038
Popot, J.L. and J.-P. Changeux (1984) Phys. Rev. 64, 1162–1239
Noda, M. et al. (1982) Nature 299, 793–797
Noda, M. et al. (1983) Nature (Lond.) 301, 251–255
Noda, M. et al. (1983) Nature (Lond.) 302, 528–532
Hucho, F., Eur. J. Biochem. 86, in press
Duguid, J.R. and Raftery, M.A. (1973) Biochem. 12, 3593–3597
Schiebler, W. and Hucho, F. (1978) Eur. J. Biochem. 85, 55–63
Martelli, S., Urban, J., and Tesche, B. (1983) Thin Solid Films 105, 49–60
Frank, J., in: Computer Processing of Electron Microscope Images, Ed. P.W. Hawkes (Springer-Verlag, Berlin 1980), pp. 187–222
Crowther, R.A. and L.A. Amos, (1971) J. Mol. Biol. 60, 123–130
Kunath, W., Giersig, M., Sack-Kongehl, H. and van Heel, M., XIth Int. Congr. on Electron Microscopy, 1986, Kyoto, Japan
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Giersig, M., Kunath, W., Sack-Kongehl, H., Hucho, F. (1986). Ultrastructural Analysis of the Native Acetylcholine Receptor. In: Maelicke, A. (eds) Nicotinic Acetylcholine Receptor. NATO ASI Series, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71649-2_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-71649-2_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71651-5
Online ISBN: 978-3-642-71649-2
eBook Packages: Springer Book Archive