A Structural Model of the Ion Channel of the Nicotinic Acetylcholine Receptor
The nicotinic acetylcholine receptor (nAChR) consists operationally of two functional parts: the signal recognition (acetylcholine binding) site and the ion channel. Both are integral parts of the heteropentameric receptor protein and appear not to be separable as molecular entities. Their interaction has been described in analogy to other allosteric proteins (1) as mediated by conformational changes of the protein conveyed from the ligand binding sites to the gating mechanism of the channel.
KeywordsHPLC Bromide Electrophoresis Serine Lysine
Unable to display preview. Download preview PDF.
- 1.)Changeux, J.-P- (1981) Harvey Lect. 75. 85–254.Google Scholar
- 2.)Karlin, A. (1980) in Cell surface reviews (Cotman, C.W., Poste,G. & Nicolson, G.L., eds.) vol. 6. pp. 191–260. North-Holland, Amsterdam.Google Scholar
- 6.)Cohen, J.B., Weber, M. & Changeux, J.-P. (1974) Mol. Pharmaco1. 10. 904–932.Google Scholar
- 11.)Oberthür, W., Muhn, P., Baumann, H., Lottspeich, F., Wittmann-Liebold, B., & Jíucho, F. (1986) EMBO J., submitted for publication.Google Scholar