The NZB × SWR Model: Insights into Viral, Immunologic, and Genetic Factors

  • S. K. Datta


The primary etiologic mechanism of systemic lupus erythematosus (SLE) is unknown. SLE in humans is probably not a single entity, but a heterogeneous group of diseases with similar clinical and immunopathologic features [1]. A genetic predisposition clearly plays a role in the development of SLE, but the genetic interactions that occur in this disorder are multiple and complex, and very little is known about the mechanism of action of such genetic factors [2]. Furthermore, the etiologic role of viruses in human SLE is disputable; retroviruses have been implicated by some investigators [3–6], whereas other have not been able to reproduce such findings [7, 8]. Discrepancies are also prevalent among the vast number of studies on the immune system in SLE [1]. It is not clear whether the immunologic abnormities are the cause of the disease or its consequence. Because of this complexity, several animal models are being investigated to define the fundamentalal mechanism of the disease.


Systemic Lupus Erythematosus Lupus Nephritis Lupus Mouse Xenotropic Virus Zealand Black Mouse 
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© Springer-Verlag Berlin Heidelberg 1987

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  • S. K. Datta

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